Literature DB >> 4052560

Binding features of diacetylmorphine (heroin) in whole blood and in blood fractions.

I Barni Comparini, E Gaggelli, N Marchettini, G Valensin.   

Abstract

Binding features of heroin in whole blood and in blood fractions were delineated by measuring the selective spin-lattice relaxation rates of heroin protons in physiologic conditions. Interaction with some receptor located in the whole human blood or in the human plasma was detected and the apparent binding constant calculated (K = 39 mol-1 dm3). Inferences about molecular dynamics of the bound heroin could be also gained.

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Year:  1985        PMID： 4052560      PMCID： PMC1329316          DOI： 10.1016/S0006-3495(85)83778-4

Source DB:  PubMed          Journal:  Biophys J        ISSN： 0006-3495            Impact factor:   4.033


  7 in total

1.  Kinetics of heroin deacetylation in aqueous alkaline solution and in human serum and whole blood.

Authors:  G R Nakamura; J I Thornton; T T Noguchi
Journal:  J Chromatogr       Date:  1975-07-02

2.  NMR parameters of local anesthetics as biological markers of the cell-virus interactions.

Authors:  P E Valensin; M L Bianchi-Bandinelli; M L di Cairano; E Gaggelli; G Valensin
Journal:  Arch Virol       Date:  1985       Impact factor: 2.574

3.  Conformational features of cell-bound drugs as detected by selective proton relaxation rate investigations.

Authors:  G Valensin; A Casini; A Lepri; E Gaggelli
Journal:  Biophys Chem       Date:  1983-06       Impact factor: 2.352

4.  Effect of morphine analogues on the conformational state of polyriboadenylic acid in solution: an NMR study.

Authors:  I B Comparini; E Gaggelli; G Valensin
Journal:  Biophys Chem       Date:  1981-11       Impact factor: 2.352

5.  Hydrolysis of diacetylmorphine (heroin) by human serum cholinesterase.

Authors:  O Lockridge; N Mottershaw-Jackson; H W Eckerson; B N La Du
Journal:  J Pharmacol Exp Ther       Date:  1980-10       Impact factor: 4.030

6.  Determination of heroin and its metabolites by high-performance liquid chromatography.

Authors:  J G Umans; T S Chiu; R A Lipman; M F Schultz; S U Shin; C E Inturrisi
Journal:  J Chromatogr       Date:  1982-12-10

7.  Diacetylmorphine (heroin) hydrolases in human blood.

Authors:  J A Owen; K Nakatsu
Journal:  Can J Physiol Pharmacol       Date:  1983-08       Impact factor: 2.273
  7 in total
  1 in total

1.  Receptors on the neutrophil membrane. I. Flunarizine-adenosine antagonism as detected by 1H-nuclear magnetic resonance relaxation investigations.

Authors:  T Di Perri; A Orrico; F Laghi Pasini; E Gaggelli; G Valensin
Journal:  Biophys J       Date:  1987-11       Impact factor: 4.033
  1 in total

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