Literature DB >> 4052098

Monoclonal antibodies against human liver cytochrome P-450.

P Beaune, P Kremers, F Letawe-Goujon, J E Gielen.   

Abstract

Monoclonal hybridomas which produce antibodies against human liver microsomal cytochrome P-450 were developed. Three similar hybridomas produced antibodies which recognized an epitope specific to a family of human P-450 isozymes (P-450(5)). This epitope was also present on cytochrome P-450 PCN-E (pregnenolone-16 alpha-carbonitrile induced) from rat liver microsomes, but this isozyme differed from the human P-450(5) by its molecular weight. These antibodies enabled us to quantify cytochrome P-450(5) in human liver microsomes and to demonstrate an important quantitative polymorphism in the human liver monooxygenase system.

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Year:  1985        PMID： 4052098     DOI： 10.1016/0006-2952(85)90732-4

Source DB:  PubMed          Journal:  Biochem Pharmacol        ISSN： 0006-2952            Impact factor:   5.858


  14 in total

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10.  Complete cDNA sequence of a cytochrome P-450 inducible by glucocorticoids in human liver.

Authors:  D T Molowa; E G Schuetz; S A Wrighton; P B Watkins; P Kremers; G Mendez-Picon; G A Parker; P S Guzelian
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