Inhibition of liver lipase in vivo leads to induction of de novo cholesterol synthesis in rat liver.

Rats were injected with control-gamma-globulins or anti-liverlipase. The anti-liverlipase treatment resulted in a 69-78% inhibition of the salt-resistant lipase activity (liver lipase) in the liver. De novo cholesterol synthesis was significantly higher in slices of livers from anti-liverlipase treated rats than from control-gamma-globulin injected rats. The anti-liverlipase treatment also affected all plasma lipoprotein fractions. If the rats had been fed a cholestyramine containing diet no effect of anti-liverlipase on cholesterol synthesis was found. In these rats the effects on plasma lipoprotein fractions were more pronounced than in the control fed rats.