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Literature DB >> 4052043

The inhibitory effect of halides and carboxylates on hepatic NADH: cytochrome b5 oxidoreductase.

Abstract

The inhibitory effect of several halides and carboxylates on bovine liver microsomal NADH: cytochrome b5 oxidoreductase (EC 1.6.2.2) was examined. The magnitude of inhibition was altered by various anion species but not by cation species. The order of effectiveness was F- less than acetate less than Cl- less than Br- less than I- less than succinate congruent to citrate. The kinetics of these inhibitions was competitive with cytochrome b5, and non-competitive with NADH, indicating that these anions inhibit the interaction of the enzyme with cytochrome b5.

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Year: 1985 PMID： 4052043 PMCID： PMC1152612 DOI： 10.1042/bj2300273

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

13 in total

1. Immunological similarity between NADH-cytochrome b5 reductase of erythrocytes and liver microsomes.

Authors: R Goto-Tamura; Y Takesue; S Takesue
Journal: Biochim Biophys Acta Date: 1976-02-16

2. The purification and properties of microsomal cytochrome reductase.

Authors: P STRITTMATTER; S F VELICK
Journal: J Biol Chem Date: 1957-10 Impact factor: 5.157

3. A new method for simultaneous purification of cytochrome b5 and NADPH-cytochrome c reductase from rat liver microsomes.

Authors: T Omura; S Takesue
Journal: J Biochem Date: 1970-02 Impact factor: 3.387

2. The opposite effect of bivalent cations on cytochrome b5 reduction by NADH:cytochrome b5 reductase and NADPH:cytochrome c reductase.

Authors: M Tamura; T Yubisui; M Takeshita
Journal: Biochem J Date: 1988-05-01 Impact factor: 3.857

2 in total

The inhibitory effect of halides and carboxylates on hepatic NADH: cytochrome b5 oxidoreductase.

1. Immunological similarity between NADH-cytochrome b5 reductase of erythrocytes and liver microsomes.

2. The purification and properties of microsomal cytochrome reductase.

3. A new method for simultaneous purification of cytochrome b5 and NADPH-cytochrome c reductase from rat liver microsomes.

4. Soluble cytochrome b 5 reductase from human erythrocytes.

5. The role of lysyl residues in the structure and reactivity of cytochrome B5 reductase.

6. The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis.

7. Properties of cytochrome b5 and methemoglobin reduction in human erythrocytes.

8. Redox properties of microsomal reduced nicotinamide adenine dinucleotide-cytochrome b5 reductase and cytochrome b5.

9. Purification and properties of soluble NADH-cytochrome b5 reductase of rabbit erythrocytes.

10. Microsomal NADH-cytochrome b5 reductase of bovine brain: purification and properties.

1. Effects of ionic strength on the functional interactions between CYP2B4 and CYP1A2.

2. The opposite effect of bivalent cations on cytochrome b5 reduction by NADH:cytochrome b5 reductase and NADPH:cytochrome c reductase.