Literature DB >> 4052032

The reaction of glutathione with the eye-lens protein gamma-crystallin.

C Slingsby, L Miller.   

Abstract

Lens cells contain high concentrations of thiol-rich proteins, gamma-crystallins and reduced glutathione. Solutions of bovine gamma-crystallin react avidly with either reduced or oxidized glutathione to form protein-glutathione mixed disulphides. A method of purification of a gamma-II crystallin-glutathione adduct containing two mixed disulphide groups is described.

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Year:  1985        PMID： 4052032      PMCID： PMC1152597          DOI： 10.1042/bj2300143

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  24 in total

Review 1.  SELECTED TOPICS IN OPHTHALMIC BIOCHEMISTRY.

Authors:  J H KINOSHITA
Journal:  Arch Ophthalmol       Date:  1964-10

2.  The molecular structure and stability of the eye lens: x-ray analysis of gamma-crystallin II.

Authors:  T Blundell; P Lindley; L Miller; D Moss; C Slingsby; I Tickle; B Turnell; G Wistow
Journal:  Nature       Date:  1981-02-26       Impact factor: 49.962

Review 3.  Structural proteins of the mammalian lens: a review with emphasis on changes in development, aging and cataract.

Authors:  J J Harding; K J Dilley
Journal:  Exp Eye Res       Date:  1976-01       Impact factor: 3.467

4.  Extensive intragenic sequence homology in two distinct rat lens gamma-crystallin cDNAs suggests duplications of a primordial gene.

Authors:  R J Moormann; J T den Dunnen; H Bloemendal; J G Schoenmakers
Journal:  Proc Natl Acad Sci U S A       Date:  1982-11       Impact factor: 11.205

5.  Total sulfhydryl by raman spectroscopy in the intact lens of several species: variations in the nucleus and along the optical axis during aging.

Authors:  J F Kuck; N T Yu; C C Askren
Journal:  Exp Eye Res       Date:  1982-01       Impact factor: 3.467

6.  The state of sulfhydryl groups in normal and cataractous human lens proteins. I. Nuclear region.

Authors:  E I Anderson; A Spector
Journal:  Exp Eye Res       Date:  1978-04       Impact factor: 3.467

7.  Structural studies on calf lens gamma-crystallin fraction IV: a comparison of the cysteine-containing tryptic peptides with the corresponding amino acid sequence of gamma-crystallin fraction II.

Authors:  C Slingsby; L R Croft
Journal:  Exp Eye Res       Date:  1978-03       Impact factor: 3.467

8.  Cleavage of lens protein-GSH mixed disulfide by glutathione reductase.

Authors:  S K Srivastava; E Beutler
Journal:  Exp Eye Res       Date:  1973-10-10       Impact factor: 3.467

9.  Studies on the crystalline lens. XII. Turnover of glycine and glutamic acid in glutathione and ophthalmic acid in the rabbit.

Authors:  D V Reddy; J Klethi; V E Kinsey
Journal:  Invest Ophthalmol       Date:  1966-12

10.  Glutathione metabolism in lenses of dogs and rabbits: activities of five enzymes.

Authors:  W B Rathbun; S S Sethna; D L Skelnik; S I Bistner
Journal:  Exp Eye Res       Date:  1983-06       Impact factor: 3.467
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  6 in total

Review 1.  Protein interactions in the calf eye lens: interactions between beta-crystallins are repulsive whereas in gamma-crystallins they are attractive.

Authors:  A Tardieu; F Vérétout; B Krop; C Slingsby
Journal:  Eur Biophys J       Date:  1992       Impact factor: 1.733

2.  Near-infrared Fourier transform Raman and conventional Raman studies of calf gamma-crystallins in the lyophilized state and in solution.

Authors:  W L Chen; S M Nie; J F Kuck; N T Yu
Journal:  Biophys J       Date:  1991-08       Impact factor: 4.033

3.  Oxidation of active cysteines mediates protein aggregation of S10R, the cataract-associated mutant of mouse GammaB-crystallin.

Authors:  Wenjuan Hou; Ajay Pande; Jayanti Pande
Journal:  Proteins       Date:  2022-07-07

4.  The identification of a reaction site of glutathione mixed-disulphide formation on gammaS-crystallin in human lens.

Authors:  Jane Craghill; Andrew D Cronshaw; John J Harding
Journal:  Biochem J       Date:  2004-05-01       Impact factor: 3.857

5.  Model for screened, charge-regulated electrostatics of an eye lens protein: Bovine gammaB-crystallin.

Authors:  Christopher W Wahle; K Michael Martini; Dawn M Hollenbeck; Andreas Langner; David S Ross; John F Hamilton; George M Thurston
Journal:  Phys Rev E       Date:  2017-09-25       Impact factor: 2.529

6.  Shotgun proteomic analysis of S-thiolation sites of guinea pig lens nuclear crystallins following oxidative stress in vivo.

Authors:  Frank J Giblin; Larry L David; Phillip A Wilmarth; Victor R Leverenz; M Francis Simpanya
Journal:  Mol Vis       Date:  2013-02-03       Impact factor: 2.367
  6 in total

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