Literature DB >> 4051835

Neurochemical changes in white matter. Aged human brain and Alzheimer's disease.

M J Malone, M C Szoke.   

Abstract

We report a reduction in isolatable myelin in white matter from regional areas of aged human brain. This decrease was most prominent in association subcortex of Alzheimer's material. We also found structural changes in myelin lipids. These changes involved an increase in unsaturated acyl chains and suggest an age-related instability of subcortical white matter. This specific chemical change in myelin glycosphingolipids has been found in all regional areas of normal aged and Alzheimer's brain material. This remains an age-related molecular change that seems unrelated to the pathophysiology of senile dementia of the Alzheimer's type.

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Year:  1985        PMID： 4051835     DOI： 10.1001/archneur.1985.04060100045019

Source DB:  PubMed          Journal:  Arch Neurol        ISSN： 0003-9942


  9 in total

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Review 9.  The Biology of Glial Cells and Their Complex Roles in Alzheimer's Disease: New Opportunities in Therapy.

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  9 in total

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