Immunoglobulins in prolonged ruptured membranes.

Concentrations of immunoglobulins G, M, and A were studied in maternal and cord serum of patients with prolonged premature rupture of membranes, as well as in properly matched control patients. None of the patients studied showed any evidence of clinical chorioamnionitis or other prenatal infections. Cases were divided into term premature rupture of membranes and term controls and preterm (less than 34 gestational weeks) premature rupture of membranes and preterm controls. In the term group, with 12 to 24 hours of premature rupture of membranes, maternal immunoglobulins M and A, and cord immunoglobulin A were significantly increased. With a duration of premature rupture of membranes of more than 24 hours, levels of immunoglobulins M and A in maternal serum and levels of immunoglobulins G and A in cord serum showed significant elevations. Levels of cord immunoglobulin M from both subgroups of patients with premature rupture of membranes showed a trend upward but were not significantly higher than those in control patients. In the preterm group, with 12 to 24 hours of premature rupture of membranes, only cord immunoglobulin A was significantly increased. With premature rupture of membranes of greater than or equal to 72 hours, only maternal immunoglobulin G increased significantly and remained elevated; immunoglobulins M and A in cord serum were also significantly increased. The significant rise in immunoglobulins in patients with premature rupture of membranes may indicate subclinical maternal and fetal infection. This suggests the possibility that subclinical infections may play a role in the etiology of premature rupture of membranes.