Literature DB >> 4049319

Quantitative analysis of the composition of mixtures of one-chain and two-chain tissue-type plasminogen activator with a spectrophotometric method.

J H Verheijen, Y F de Jong, G T Chang.   

Abstract

Tissue-type plasminogen activator (t-PA) exists in two active forms, one-chain t-PA and two-chain t-PA. These two forms differ in their kinetic constants for certain substrates. An assay has been devised to determine the composition of unknown mixtures of both t-PA forms, using the activity measurement on two different substrates. The best results are obtained using plasminogen and less than Glu-Pro-Arg-pNA as substrates.

Entities:  

Mesh：

Substances：

Year:  1985        PMID： 4049319     DOI： 10.1016/0049-3848(85)90223-3

Source DB:  PubMed          Journal:  Thromb Res        ISSN： 0049-3848            Impact factor:   3.944


  6 in total

1.  Efficacy of histotripsy combined with rt-PA in vitro.

Authors:  Kenneth B Bader; Kevin J Haworth; Himanshu Shekhar; Adam D Maxwell; Tao Peng; David D McPherson; Christy K Holland
Journal:  Phys Med Biol       Date:  2016-06-29       Impact factor: 3.609

2.  In vitro thrombolytic efficacy of echogenic liposomes loaded with tissue plasminogen activator and octafluoropropane gas.

Authors:  Himanshu Shekhar; Kenneth B Bader; Shenwen Huang; Tao Peng; Shaoling Huang; David D McPherson; Christy K Holland
Journal:  Phys Med Biol       Date:  2016-12-21       Impact factor: 3.609

3.  Ultrasound-triggered release of recombinant tissue-type plasminogen activator from echogenic liposomes.

Authors:  Denise A B Smith; Sampada S Vaidya; Jonathan A Kopechek; Shao-Ling Huang; Melvin E Klegerman; David D McPherson; Christy K Holland
Journal:  Ultrasound Med Biol       Date:  2010-01       Impact factor: 2.998

4.  Asn and asn: critical residues for in vitro biological activity of reteplase.

Authors:  Naganath Mandi; Kalyana R Sundaram; Sunil K Tandra; Suman Bandyopadhyay; Sriram Padmanabhan
Journal:  Adv Hematol       Date:  2010-06-21

5.  Thrombolytic efficacy and enzymatic activity of rt-PA-loaded echogenic liposomes.

Authors:  Kenneth B Bader; Guillaume Bouchoux; Tao Peng; Melvin E Klegerman; David D McPherson; Christy K Holland
Journal:  J Thromb Thrombolysis       Date:  2015-08       Impact factor: 2.300

6.  Accelerated sonothrombolysis with Definity in a xenographic porcine cerebral thromboembolism model.

Authors:  Robert T Kleven; Kunal B Karani; Nicole Hilvert; Samantha M Ford; Karla P Mercado-Shekhar; John M Racadio; Marepalli B Rao; Todd A Abruzzo; Christy K Holland
Journal:  Sci Rep       Date:  2021-02-17       Impact factor: 4.379
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.