Literature DB >> 404708

Covalent labeling of the tetrodotoxin receptor in excitable membranes.

R J Guillory, M D Rayner, J S D'Arrigo.   

Abstract

A photoaffinity labeling technique is described by which a tetrodotoxin analog is covalently bound to receptor sites associated with the sodium pores of excitable membranes. The biological activity of the toxin analog is retained after the covalent binding reaction.

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Year:  1977        PMID： 404708     DOI： 10.1126/science.404708

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  4 in total

Review 1.  Chemical and Biological Tools for the Study of Voltage-Gated Sodium Channels in Electrogenesis and Nociception.

Authors:  Anna V Elleman; J Du Bois
Journal:  Chembiochem       Date:  2022-03-21       Impact factor: 3.461

2.  Photoaffinity labeling of the tetrodotoxin binding component of Electrophorus electricus electroplax.

Authors:  S Uehara; K Uyemura
Journal:  Neurochem Res       Date:  1985-08       Impact factor: 3.996

3.  Active groups of saxitoxin and tetrodotoxin as deduced from actions of saxitoxin analogues on frog muscle and squid axon.

Authors:  C Y Kao; S E Walker
Journal:  J Physiol       Date:  1982-02       Impact factor: 5.182

4.  De novo synthesis of modified saxitoxins for sodium ion channel study.

Authors:  Brian M Andresen; J Du Bois
Journal:  J Am Chem Soc       Date:  2009-09-09       Impact factor: 15.419
  4 in total

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