Literature DB >> 4046736

Reduced mechanical activity of perfused rat heart following morphine or enkephalin peptides administration.

C Clô, C Muscari, B Tantini, C Pignatti, P Bernardi, C Ventura.   

Abstract

In the isolated and perfused rat heart, the addition of morphine, methionine-enkephalin or leucine-enkephalin to the coronary perfusate, significantly reduces the mechanical activity by negatively affecting both the heart rate and the developed tension. These effects are dose dependent and maximally evident with leucine-enkephalin. Furthermore all the opioids strongly reduce the activity of isoproterenol-stimulated hearts. The suggestion is made that opioid peptides directly influence the cardiac mechanical activity possibly by interacting with membrane-receptor systems.

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Year:  1985        PMID： 4046736     DOI： 10.1016/0024-3205(85)90248-6

Source DB:  PubMed          Journal:  Life Sci        ISSN： 0024-3205            Impact factor:   5.037


  5 in total

1.  Effect of dynorphin A(1-13) on cardiomyocytes in culture: modulation of the response to increased extracellular calcium, but no effect on intrinsic cardiac contractile frequency or the response to isoproterenol or increased extracellular potassium.

Authors:  S W Rabkin
Journal:  Basic Res Cardiol       Date:  1992 May-Jun       Impact factor: 17.165

2.  Opioids stimulate sarcolemmal NAD(P)H-vanadate dehydrogenase activity.

Authors:  C Ventura; C Guarnieri; L Bastagli; C M Caldarera
Journal:  Basic Res Cardiol       Date:  1988 Jul-Aug       Impact factor: 17.165

3.  Hypertensive state, independent of hypertrophy, exhibits an attenuated decrease in systolic function on cardiac kappa-opioid receptor stimulation.

Authors:  Craig Bolte; Gilbert Newman; Jo El J Schultz
Journal:  Am J Physiol Heart Circ Physiol       Date:  2009-01-30       Impact factor: 4.733

Review 4.  Intracrine Endorphinergic Systems in Modulation of Myocardial Differentiation.

Authors:  Silvia Canaider; Federica Facchin; Riccardo Tassinari; Claudia Cavallini; Elena Olivi; Valentina Taglioli; Chiara Zannini; Eva Bianconi; Margherita Maioli; Carlo Ventura
Journal:  Int J Mol Sci       Date:  2019-10-18       Impact factor: 5.923

Review 5.  Endogenous Opioids and Their Role in Stem Cell Biology and Tissue Rescue.

Authors:  Giovannamaria Petrocelli; Luca Pampanella; Provvidenza M Abruzzo; Carlo Ventura; Silvia Canaider; Federica Facchin
Journal:  Int J Mol Sci       Date:  2022-03-30       Impact factor: 5.923
  5 in total

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