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Literature DB >> 404520

Mitochondrial biogenesis: inhibitors of mitochondrial protein synthesis.

Abstract

The effects of erythromycin, chloramphenicol, cycloheximide, pyrimethamine, chromate, cadmium, lead, nickel, 4-nitro-quinoline-1-oxide and thioacetamide on yeast and human cells were studied. Inhibition of the synthesis of mitochondrial proteins resulted in the loss of cytochromes as well as in morphological changes in the cellular membranes and mitotic arrest. The data are discussed.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1977 PMID： 404520 DOI： 10.1007/bf01734171

Source DB: PubMed Journal: Mol Cell Biochem ISSN： 0300-8177 Impact factor: 3.396

14 in total

1. Effect of pyrimethamine on the morphology and ultrastructure of Saccharomyces cerevisiae.

Authors: A B Stone; D G Smith; D Wilkie
Journal: Microbios Date: 1975

2. Comparative distribution of cytochrome oxidase, succinate permease, and fixed anionic sites on the intact inner mitochondrial membrane. Polycationic ferritin as a visually detectable metabolic inhibitor.

Authors: C R Hackenbrock
Journal: Arch Biochem Biophys Date: 1975-09 Impact factor: 4.013

3. Limited ability of thymidine to relieve mitotic inhibition by pyrimethamine in human fibroblasts.

Authors: D Kirk; U Mittwoch; A B Stone; D Wilkie
Journal: Biochem Pharmacol Date: 1976-03-15 Impact factor: 5.858

Review 4. Biogenetic autonomy of mitochondria.

Authors: H R Mahler
Journal: CRC Crit Rev Biochem Date: 1973-08

Review 5. Stabilization of the enzymatic systems of the inner mitochondrial membrane and related problems. A possible approach to the problem of the regulation of mitochondrial formation.

Authors: V N Luzikov
Journal: Subcell Biochem Date: 1973-01

6. Induction of mitochondrial RNA polymerase in Neurospora crassa.

Authors: Z Barath; H Küntzel
Journal: Nat New Biol Date: 1972-12-13

7. Cytochrome b in Neurospora crassa mitochondria. A membrane protein containing subunits of cytoplasmic and mitochondrial origin.

Authors: H Weiss
Journal: Eur J Biochem Date: 1972-11-07

Review 8. Biosynthesis of mitochondrial enzymes.

Authors: A Tzagoloff; M S Rubin; M F Sierra
Journal: Biochim Biophys Acta Date: 1973-02-12

9. Induction of the cytoplasmic petite mutation in Saccharomyces cerevisiae by the antibacterial antibiotics erythromycin and chloramphenicol.

Authors: D H Williamson; N G Maroudas; D Wilkie
Journal: Mol Gen Genet Date: 1971