Mitochondrial injury of pulmonary alveolar epithelial cells in acute paraquat intoxication.

The primary ultrastructural changes in pulmonary alveolar epithelial cells are described in paraquat-injected rats. Within 6-12 hr a single intravenous injection of 40 mg/kg paraquat dichloride caused selective mitochondrial swelling and loss of intramitochondrial granules within 24 hr in alveolar Type II cells. As the mitochondrial injury advanced, microvilli disappeared from apical plasma membrane followed by a cell destruction and detachment from basement membrane. This was accompanied by secondary damage to Type II cells and interstitial cells. These results indicate that paraquat may affect primarily the Type II cells and the first lesion produced occurs in mitochondria.