Literature DB >> 4043173

Activity of titanocene dihalides against a human colon carcinoma heterotransplanted to athymic mice.

P Köpf-Maier, A Moormann, H Köpf.   

Abstract

The antitumor activity of cis-diamminedichloroplatinum (II) and of two metallocene derivatives, titanocene dichloride (C5H5)2TiCl2 and titanocene dibromide (C5H5)2TiBr2, was investigated against a human colon adenocarcinoma heterotransplanted to athymic mice. The substances were administered at various doses on a Q2DX5 or a Q3DX5 schedule. Whereas cis-diamminedichloroplatinum (II) induced an only marginal tumor-inhibiting effect, both titanocenes markedly suppressed tumor development (T/C values: 23-40%) and caused stagnation and relative decrease of tumor growth, when they were applied in subtoxic doses far below the LD10 level. The results are remarkable with respect to the general insensitivity of human colorectal carcinomas to cytostatic agents.

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Year:  1985        PMID： 4043173     DOI： 10.1016/0277-5379(85)90225-1

Source DB:  PubMed          Journal:  Eur J Cancer Clin Oncol        ISSN： 0277-5379


  10 in total

1.  Pattern of toxicity by titanocene dichloride in mice. Blood and urine chemical parameters.

Authors:  P Köpf-Maier; S Gerlach
Journal:  J Cancer Res Clin Oncol       Date:  1986       Impact factor: 4.553

2.  Tumor inhibition by titanocene complexes: influence upon two xenografted human lung carcinomas.

Authors:  P Köpf-Maier
Journal:  J Cancer Res Clin Oncol       Date:  1987       Impact factor: 4.553

3.  Antitumor activity of bent metallocenes: electronic structure analysis using DFT computations.

Authors:  Dhurairajan Senthilnathan; Sundararajan Vaideeswaran; Ponnambalam Venuvanalingam; Gernot Frenking
Journal:  J Mol Model       Date:  2010-05-22       Impact factor: 1.810

4.  Interaction of metallocene dichlorides with apo-human transferrin: A spectroscopic study and cytotoxic activity against human cancer cell lines.

Authors:  Jorge R Güette Fernández; Xiomara Narváez Pita; Enrique Meléndez; Elsie I Parés Matos
Journal:  Int J Mol Biol (Edmond)       Date:  2020-07-31

Review 5.  [Cytostatic non-platinum metal complexes: new perspectives for the treatment of cancer?].

Authors:  P Köpf-Maier
Journal:  Naturwissenschaften       Date:  1987-08

6.  Tumor inhibition by titanocene complexes: influence on xenografted human adenocarcinomas of the gastrointestinal tract.

Authors:  P Köpf-Maier
Journal:  Cancer Chemother Pharmacol       Date:  1989       Impact factor: 3.333

Review 7.  Cancer risk from inorganics.

Authors:  S H Swierenga; J P Gilman; J R McLean
Journal:  Cancer Metastasis Rev       Date:  1987       Impact factor: 9.264

8.  Histologic and ultrastructural alterations of a xenografted human colon adenocarcinoma after treatment with titanocene dichloride.

Authors:  P Köpf-Maier
Journal:  J Cancer Res Clin Oncol       Date:  1988       Impact factor: 4.553

9.  In vitro evaluation of platinum, titanium and ruthenium metal complexes in cisplatin-sensitive and -resistant rat ovarian tumors.

Authors:  S Frühauf; W J Zeller
Journal:  Cancer Chemother Pharmacol       Date:  1991       Impact factor: 3.333

10.  Anti-proliferative activity and mechanism of action of titanocene dichloride.

Authors:  C V Christodoulou; A G Eliopoulos; L S Young; L Hodgkins; D R Ferry; D J Kerr
Journal:  Br J Cancer       Date:  1998-06       Impact factor: 7.640
  10 in total

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