Literature DB >> 4043057

Activity of BAY n 7133 and BAY 1 9139 in vitro and in experimental murine coccidioidomycosis.

P D Hoeprich, J M Merry.   

Abstract

The activity of two new antifungal azoles, BAY n 7133 and BAY 1 9139, against Coccidioides immitis was compared with that of ketoconazole in vitro and in experimental murine coccidioidomycosis. Daily intravenous injections were given for 30 days. All mice were autopsied and suspensions of lung, liver and spleen cultured. BAY n 7133 was as active as ketoconazole while Bay 1 9139 was les active. All three drugs were coccidioidostatic only both in vitro and in vivo.

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Year:  1985        PMID： 4043057     DOI： 10.1007/bf02148692

Source DB:  PubMed          Journal:  Eur J Clin Microbiol        ISSN： 0722-2211            Impact factor:   3.267


  6 in total

1.  The assay of virulence of Coccidioides in white mice.

Authors:  L FRIEDMAN; C E SMITH; L E GORDON
Journal:  J Infect Dis       Date:  1955 Nov-Dec       Impact factor: 5.226

Review 2.  Chemotherapy of the systemic mycoses.

Authors:  J P Utz
Journal:  Med Clin North Am       Date:  1982-01       Impact factor: 5.456

3.  A direct comparison of oral treatments with BAY-n-7133, BAY-1-9139 and ketoconazole in experimental murine coccidioidomycosis.

Authors:  H B Levine
Journal:  Sabouraudia       Date:  1984

4.  Treatment of systemic mycoses with ketoconazole: emphasis on toxicity and clinical response in 52 patients. National Institute of Allergy and Infectious Diseases collaborative antifungal study.

Authors:  W E Dismukes; A M Stamm; J R Graybill; P C Craven; D A Stevens; R L Stiller; G A Sarosi; G Medoff; C R Gregg; H A Gallis; B T Fields; R L Marier; T A Kerkering; L G Kaplowitz; G Cloud; C Bowles; S Shadomy
Journal:  Ann Intern Med       Date:  1983-01       Impact factor: 25.391

5.  Reproducible method for induction of pulmonary coccidioidomycosis in mice.

Authors:  R M Lawrence; A C Huston; P D Hoeprich
Journal:  J Infect Dis       Date:  1977-01       Impact factor: 5.226

6.  In vitro activities of two new antifungal azoles.

Authors:  P D Hoeprich; J M Merry
Journal:  Antimicrob Agents Chemother       Date:  1984-03       Impact factor: 5.191
  6 in total
  1 in total

Review 1.  Overview of medically important antifungal azole derivatives.

Authors:  R A Fromtling
Journal:  Clin Microbiol Rev       Date:  1988-04       Impact factor: 26.132
  1 in total

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