| Literature DB >> 4042465 |
G Koren, T F Chin, J Correia, A Tesoro, S M MacLeod.
Abstract
The influence of 3-9 months of combined low dose oral contraceptives on theophylline pharmacokinetics was studied in 10 adolescent females (age 15-18 years, mean +/- SD 17 +/- 1) and compared to 10 age-matched control subjects (age 13.8-19 years, mean +/- SD 16.5 +/- 1.6). The distribution volume (0.44 +/- 0.06 L/kg in control vs. 0.44 +/- 0.09 L/kg oral contraceptive group), total body clearance (0.78 +/- 0.13 ml/kg/min vs 0.78 +/- 0.18 ml/kg/min) and elimination T 1/2 (402 +/- 78 min vs. 409 +/- 126 min) were identical in the two groups. It appears that during the first 3-9 months of low dose oral contraceptive treatment, these steroids do not alter the pharmacokinetic behaviour of theophylline in adolescent females.Entities:
Keywords: Adolescents; Adolescents, Female; Age Factors; Alcohol Drinking; Americas; Behavior; Canada; Clinical Research; Contraception--side effects; Contraceptive Agents, Female--side effects; Contraceptive Agents--side effects; Contraceptive Methods--pharmacodynamics; Contraceptive Methods--side effects; Demographic Factors; Developed Countries; Developing Countries; Drugs--administraction and dosage; Family Planning; Menstrual Cycle; Menstruation; North America; Northern America; Oral Contraceptives--pharmacodynamics; Oral Contraceptives--side effects; Population; Population Characteristics; Reproduction; Research Methodology; Smoking; Social Behavior; Treatment; Youth
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Year: 1985 PMID： 4042465
Source DB: PubMed Journal: Clin Invest Med ISSN： 0147-958X Impact factor: 0.825