Literature DB >> 4042022

Acetylcholine supersensitivity in the rat heart produced by neonatal sympathectomy.

K Ishii, N Ishii, K Shigenobu, Y Kasuya.   

Abstract

Effects of neonatal sympathectomy with antiserum to nerve growth factor or 6-hydroxydopamine on the acetylcholine sensitivity of the rat left atria were investigated. Sensitivities to acetylcholine of atria from immunologically and chemically sympathectomized rats were much higher than that of control at 4 weeks of age. These results suggest possible involvement of the sympathetic nervous system in regulation of cardiac cholinergic sensitivity.

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Year:  1985        PMID: 4042022     DOI: 10.1139/y85-147

Source DB:  PubMed          Journal:  Can J Physiol Pharmacol        ISSN: 0008-4212            Impact factor:   2.273


  3 in total

1.  Role of beta-adrenoceptor-adenylate cyclase system in the developmental decrease in sensitivity to isoprenaline in foetal and neonatal rat heart.

Authors:  H Tanaka; K Shigenobu
Journal:  Br J Pharmacol       Date:  1990-05       Impact factor: 8.739

2.  Chronotropic and inotropic effects of histamine in developing chick heart: differential mechanisms before and after hatching.

Authors:  H Tanaka; N Uesato; K Shigenobu
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1995-04       Impact factor: 3.000

3.  Sustained negative inotropism mediated by alpha-adrenoceptors in adult mouse myocardia: developmental conversion from positive response in the neonate.

Authors:  H Tanaka; S Manita; T Matsuda; M Adachi; K Shigenobu
Journal:  Br J Pharmacol       Date:  1995-02       Impact factor: 8.739

  3 in total

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