| Literature DB >> 4041852 |
R Oishi, Y Itoh, M Nishibori, K Saeki.
Abstract
Histamine (HA) turnover rate in the brain of spontaneously hypertensive rats (SHR) was determined by the accumulation of telemethylhistamine after pargyline treatment. The values in these SHR were lower than in the Wistar Kyoto rats, particularly in the hypothalamus and brainstem. However, chronic treatment with L-histidine had no effect on the development of hypertension in the SHR. The functional significance of the decreased HA turnover in SHR is discussed in relation to the pathogenesis of hypertension.Entities:
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Year: 1985 PMID： 4041852 DOI： 10.1016/0006-8993(85)91175-8
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252