Literature DB >> 4040745

Successful in vitro growth of human head and neck cancer after transplantation in nude mice.

E C Heinerman, B J Braakhuis, G H Boerrigter, G B Snow.   

Abstract

Head and neck tumours from 14 different lines growing in athymic nude mice were cultured in a soft agar cloning assay. Eleven lines (79%) demonstrated growth with more than 100 colonies per 3 X 10(5) cells plated. These results are much more favourable than those obtained with head and neck tumours taken directly from the patient. It is suggested that the combination of the athymic nude mouse xenograft model with the clonogenic assay could serve as a new screening model for chemotherapeutic agents against head and neck cancer.

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Year:  1985        PMID： 4040745     DOI： 10.1007/bf00453692

Source DB:  PubMed          Journal:  Arch Otorhinolaryngol        ISSN： 0302-9530


  17 in total

1.  Chemotherapy of human colon cancer xenografts in athymic nude mice.

Authors:  R Osieka; D P Houchens; A Goldin; R K Johnson
Journal:  Cancer       Date:  1977-11       Impact factor: 6.860

2.  Chemotherapy of a human malignant melanoma transplanted in the nude mouse.

Authors:  C O Povlsen; G K Jacobsen
Journal:  Cancer Res       Date:  1975-10       Impact factor: 12.701

3.  Cloning efficiency. A possible prognostic indicator in squamous cell carcinoma of the head and neck.

Authors:  M E Johns; S E Mills
Journal:  Cancer       Date:  1983-10-15       Impact factor: 6.860

4.  The human tumour xenograft--a valid model in experimental chemotherapy?

Authors:  A J Shorthouse; J F Smyth; G G Steel; M Ellison; J Mills; M J Peckham
Journal:  Br J Surg       Date:  1980-10       Impact factor: 6.939

5.  Factors that influence growth of head and neck squamous carcinoma in the soft agar cloning assay.

Authors:  D E Mattox; D D Von Hoff; G M Clark; T B Aufdemorte
Journal:  Cancer       Date:  1984-04-15       Impact factor: 6.860

6.  Chemosensitivity testing of human solid tumors. A review of 1582 assays with 258 clinical correlations.

Authors:  C A Bertelsen; V K Sondak; B D Mann; E L Korn; D H Kern
Journal:  Cancer       Date:  1984-03-15       Impact factor: 6.860

7.  Prospective clinical trial of a human tumor cloning system.

Authors:  D D Von Hoff; G M Clark; B J Stogdill; M F Sarosdy; M T O'Brien; J T Casper; D E Mattox; C P Page; A B Cruz; J F Sandbach
Journal:  Cancer Res       Date:  1983-04       Impact factor: 12.701

8.  In vitro growth and drug sensitivity of tumor colony-forming units from human tumor xenografts.

Authors:  R Taetle; A K Koessler; S B Howel
Journal:  Cancer Res       Date:  1981-05       Impact factor: 12.701

9.  Cell aggregates in the soft agar "human tumour stem-cell assay".

Authors:  M V Agrez; J S Kovach; M M Lieber
Journal:  Br J Cancer       Date:  1982-12       Impact factor: 7.640

10.  Chemotherapy of human head and neck cancer xenografts with three clinically active drugs: cis-platinum, bleomycin and methotrexate.

Authors:  B J Braakhuis; E J Schoevers; E C Heinerman; G Sneeuwloper; G B Snow
Journal:  Br J Cancer       Date:  1983-11       Impact factor: 7.640
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  2 in total

1.  Chemosensitivity of head and neck cancer with the rapid thymidine incorporation assay and its clinical application.

Authors:  H Saito; T Ohtsubo; S Fujieda; N Tanigawa
Journal:  Eur Arch Otorhinolaryngol       Date:  1992       Impact factor: 2.503

2.  Chemosensitivity of human head and neck cancer xenografts in the clonogenic assay and in nude mice.

Authors:  G H Boerrigter; E C Heinerman; B J Braakhuis; G B Snow
Journal:  Br J Cancer       Date:  1986-07       Impact factor: 7.640
  2 in total

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