| Literature DB >> 403949 |
C Gatti, C Houssier, E Fredericq.
Abstract
It is shown in this work that the binding of ethidium bromide to yeast ribosomes occurs through intercalation in the double-stranded rRNA regions and produces changes in the ribosomes structure, yielding unfolded subparticles, and even partial separation of proteins from rRNA at very high binding ratios. The addition of Mg2+ prevents these structural changes, probably by partial inhibition of the dye binding.Entities:
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Year: 1977 PMID： 403949 DOI： 10.1016/0005-2787(77)90286-6
Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002