[Synthesis of anticholinergically active N-alkylnorscopolamines and their quaternary salts with special consideration of the bronchospasmolytic (-)-N-ethylnorscopolamine methobromide (Ba 253 BR)].

The synthesis of anticholinergic N-alkylnorscopolamines and their quaternary salts, especially the synthesis of (-)-N-ethylnorscopolamin methobromide (Ba 253 BR), is reported. (-)-N-Ethylnorscopolamine methobromide differs from the stereoisomeric (-)-N-ethylscopolammonium bromide not only by its physico-chemical, but also by its pharmacological properties. (-)-N-Ethylnorscopolamine methobromide represents an anticholinergic bronchodilator with long duration of action.