| Literature DB >> 4038420 |
W D Myers, L Mackenzie, K T Ng, G Singer, G A Smythe, M W Duncan.
Abstract
Endogenous levels of salsolinol and dopamine were measured by a gas chromatography/mass spectrometry (GC/MS) - selected ion monitoring technique using deuterated internal standards in Long Evans rats chronically exposed to ethanol for ten months. Chronic ethanol exposure produced significant increases of dopamine and salsolinol concentrations in the medial basal hypothalamus but not striatum. The data suggest that the occurrence of salsolinol in rat brain tissue is a consequence of an in vivo Pictet-Spengler cyclization.Entities:
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Year: 1985 PMID： 4038420 DOI： 10.1016/0024-3205(85)90115-8
Source DB: PubMed Journal: Life Sci ISSN： 0024-3205 Impact factor: 5.037