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Literature DB >> 4037905

The influence of splenic weight and function on survival after experimental pneumococcal infection.

M A Malangoni, L G Dawes, E A Droege, U A Almagro.

Abstract

Splenectomy impairs survival after pneumococcal challenge in rats, while preservation of sufficient splenic tissue can be protective. This study investigated the effects of methylcellulose on stimulation of splenic weight, splenic histology, reticuloendothelial (RE) activity, and survival after pneumococcal infection. Methylcellulose increased spleen weight four- to five-fold but did not improve RE function or survival after infection. These parameters correlated best with the weight of the remnant in animals that did not receive methylcellulose. The functional limitations of splenic autotransplants were not corrected by methylcellulose stimulation of splenic weight. Preservation of a splenic remnant with intact blood supply is preferable to autotransplantation of the spleen to conserve RE capability.

Entities: Chemical Disease Species

Mesh：

Substances：
Methylcellulose

Year: 1985 PMID： 4037905 PMCID： PMC1250907 DOI： 10.1097/00000658-198509000-00008

Source DB: PubMed Journal: Ann Surg ISSN： 0003-4932 Impact factor: 12.969

16 in total

1. The effects of methyl cellulose in rats with special reference to splenomegaly, anaemia and the problem of hypersplenism.

Authors: T B TEOH
Journal: J Pathol Bacteriol Date: 1961-01

2. The experimental production of splenomegaly, anemia and leukopenia in Albino rats.

Authors: J G PALMER; E J EICHWALD; G E CARTWRIGHT; M M WINTROBE
Journal: Blood Date: 1953-01 Impact factor: 22.113

3. Relative merits of partial splenectomy, splenic reimplantation, and immunization in preventing postsplenectomy infection.

Authors: D R Cooney; J C Dearth; S E Swanson; M K Dewanjee; R L Telander
Journal: Surgery Date: 1979-10 Impact factor: 3.982

10. Effect of splenic sequestration of erythrocytes on splenic clearance function and susceptibility to septic peritonitis.

Authors: G J Grover; D J Loegering
Journal: Infect Immun Date: 1982-04 Impact factor: 3.441

2 in total

1. Splenic artery ligation: a ten-year experience in the treatment of selected cases of splenic injuries in children.

Authors: D Keramidas; C Büyükünal; O Senyüz; T Dolatzas
Journal: Jpn J Surg Date: 1991-03

2. Autologous splenic transplantation for splenic trauma.

Authors: P W Pisters; H L Pachter
Journal: Ann Surg Date: 1994-03 Impact factor: 12.969

2 in total

The influence of splenic weight and function on survival after experimental pneumococcal infection.

1. The effects of methyl cellulose in rats with special reference to splenomegaly, anaemia and the problem of hypersplenism.

2. The experimental production of splenomegaly, anemia and leukopenia in Albino rats.

3. Relative merits of partial splenectomy, splenic reimplantation, and immunization in preventing postsplenectomy infection.

4. A scanning electron microscopic study of the spleen.

5. Critical splenic mass for survival from experimental pneumococcemia.

6. Regeneration of heterotopically transplanted autologous splenic tissue.

7. Improved survival after pneumococcus in splenectomized and nonsplenectomized mice with Corynebacterium parvum.

8. Protective effect of nonspecific immunostimulation in postsplenectomy sepsis.

9. The effect of the immunomodulator corynebacterium parvum on hemisplenectomized mice.

10. Effect of splenic sequestration of erythrocytes on splenic clearance function and susceptibility to septic peritonitis.

1. Splenic artery ligation: a ten-year experience in the treatment of selected cases of splenic injuries in children.

2. Autologous splenic transplantation for splenic trauma.