Automatic control of blood pressures with multiple drug inputs.

Control of arterial blood pressure has been successfully achieved by infusing a single vasoactive drug. However, in clinical practice, blood pressures are frequently controlled using multiple drug infusions. This paper presents a computer based adaptive control algorithm for simultaneous infusions of both an inotropic agent and a vasoactive agent to maintain the blood pressures at desired levels. We present the dynamics of the system with a bilinear two-input, two-output model. A least-squares parameter estimation algorithm has been employed using an output error method. Results of computer simulations of an electrical analog model of the heart and circulatory system are presented.