Literature DB >> 4036169

Carnitine and glucuronic acid conjugates of pivalic acid.

S Vickers, C A Duncan, S D White, H G Ramjit, J L Smith, R W Walker, H Flynn, B H Arison.   

Abstract

The [1-14C]pivaloyloxyethyl ester of methyldopa administered to man and cynomolgus monkeys resulted in the elimination in the urine of 14C-pivalic acid metabolites. Pivaloyl glucuronide and pivaloyl carnitine were identified as the major radioactive urinary metabolites in monkey urine and human urine, respectively. N.m.r. analysis indicated that pivaloyl carnitine had a cyclic structure. Although the role of carnitine is in the transport of fatty acids across mitochondrial membranes, it may also function in the conjugation of carboxylic acid xenobiotics in humans.

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Year:  1985        PMID： 4036169     DOI： 10.3109/00498258509045018

Source DB:  PubMed          Journal:  Xenobiotica        ISSN： 0049-8254            Impact factor:   1.908


  5 in total

1.  Induction of peroxisomal beta-oxidation and P-450 4A-dependent activities by pivalic and trichloroacetic acid in rat liver and kidney.

Authors:  U Zanelli; P Puccini; D Acerbi; P Ventura; P G Gervasi
Journal:  Arch Toxicol       Date:  1996       Impact factor: 5.153

2.  Phase I clinical studies of S-1108: safety and pharmacokinetics in a multiple-administration study with special emphasis on the influence on carnitine body stores.

Authors:  M Nakashima; T Uematsu; T Oguma; T Yoshida; K Mizojiri; S Matsuno; S Yamamoto
Journal:  Antimicrob Agents Chemother       Date:  1992-04       Impact factor: 5.191

3.  Metabolism of S-1108, a new oral cephem antibiotic, and metabolic profiles of its metabolites in humans.

Authors:  K Totsuka; K Shimizu; M Konishi; S Yamamoto
Journal:  Antimicrob Agents Chemother       Date:  1992-04       Impact factor: 5.191

4.  Metabolic fate of 2,2-dimethylbutyryl moiety of simvastatin in rats: identification of metabolites by gas chromatography/mass spectrometry.

Authors:  N Uchiyama; Y Kagami; Y Saito; S Abe; M Ohtawa; S Hata
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1991 Jul-Sep       Impact factor: 2.441

5.  Disposition of S-1108, a new oral cephem antibiotic, and metabolic fate of pivalic acid liberated from [pivaloyl-14C]S-1108 in rats and dogs.

Authors:  K Mizojiri; S Futaguchi; R Norikura; Y Katsuyama; T Nagasaki; T Yoshimori; M Nakanishi
Journal:  Antimicrob Agents Chemother       Date:  1995-07       Impact factor: 5.191
  5 in total

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