Literature DB >> 4035709

Teratogenic potency of TCDD, TCDF and TCDD-TCDF combinations in C57BL/6N mice.

H Weber, M W Harris, J K Haseman, L S Birnbaum.   

Abstract

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and 2,3,7,8-tetrachlorodibenzofuran (TCDF) cause the same spectrum of fetal anomalies in C57BL/6N mice. Pregnant dams were treated with TCDD, TCDF and combinations of the 2 compounds on gestation day 10, and examined for maternal and fetal effects on day 18. The fetal kidneys were the most sensitive target for teratogenicity. The dose response for cleft palate induction fit the probit model for both compounds, suggesting that TCDD was approximately 30 times more potent than TCDF. The interaction between these 2 compounds was consistent with a model for additive toxicity.

Entities:  

Mesh：

Substances：

Year:  1985        PMID： 4035709     DOI： 10.1016/0378-4274(85)90161-4

Source DB:  PubMed          Journal:  Toxicol Lett        ISSN： 0378-4274            Impact factor:   4.372


  8 in total

1.  A single mid-gestation exposure to TCDD yields a postnatal autoimmune signature, differing by sex, in early geriatric C57BL/6 mice.

Authors:  A Mustafa; S D Holladay; S Witonsky; D P Sponenberg; E Karpuzoglu; R M Gogal
Journal:  Toxicology       Date:  2011-09-06       Impact factor: 4.221

2.  Microcontaminants and reproductive impairment of the Forster's tern on Green Bay, Lake Michigan--1983.

Authors:  T J Kubiak; H J Harris; L M Smith; T R Schwartz; D L Stalling; J A Trick; L Sileo; D E Docherty; T C Erdman
Journal:  Arch Environ Contam Toxicol       Date:  1989-09       Impact factor: 2.804

3.  2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and 2,3,7,8-tetrachlorodibenzofuran (TCDF) in pregnant C57BL/6N mice: distribution to the embryo and excretion.

Authors:  H Weber; L S Birnbaum
Journal:  Arch Toxicol       Date:  1985-08       Impact factor: 5.153

4.  H4IIE rat hepatoma cell bioassay-derived 2,3,7,8-tetrachlorodibenzo-p-dioxin equivalents in colonial fish-eating waterbird eggs from the Great Lakes.

Authors:  D E Tillitt; G T Ankley; D A Verbrugge; J P Giesy; J P Ludwig; T J Kubiak
Journal:  Arch Environ Contam Toxicol       Date:  1991-07       Impact factor: 2.804

5.  2,3,7,8 Tetrachlorodibenzodioxin in fish from the Pigeon River of eastern Tennessee, USA: its toxicity and mutagenicity as revealed by the Ames Salmonella assay.

Authors:  R D Blevins
Journal:  Arch Environ Contam Toxicol       Date:  1991-04       Impact factor: 2.804

6.  Long non-coding RNA H19-mediated mouse cleft palate induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin.

Authors:  Liyun Gao; Jun Yin; Weidong Wu
Journal:  Exp Ther Med       Date:  2016-03-24       Impact factor: 2.447

7.  Comparative toxicity of four chlorinated dibenzo-p-dioxins (CDDs) and their mixture. Part I: Acute toxicity and toxic equivalency factors (TEFs).

Authors:  B U Stahl; A Kettrup; K Rozman
Journal:  Arch Toxicol       Date:  1992       Impact factor: 5.153

8.  Windows of Sensitivity to Toxic Chemicals in the Development of Cleft Palates.

Authors:  M C Buser; H R Pohl
Journal:  J Toxicol Environ Health B Crit Rev       Date:  2015-08-20       Impact factor: 6.393
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.