Literature DB >> 403553

Mass fragmentographic analysis of clomipramine and its mono-demethylated metabolite in human plasma.

G Alfredsson, F A Wiesel, B Fyro, G Sedvall.   

Abstract

A mass fragmentographic method for the quantification of clomipramine (CIM) and monodemethyl-clomipramine (DCIM) in human plasma was developed. The deuterium labelled analogues of the compounds were used as internal standards. The sensitivity of the method allows the determination of CIM and DCIM in plasma after oral doses with a standard deviation less than 7% at concentrations of 25 ng/ml. The method was applied to the analysis of drug concentrations in plasma of clomipramine treated healthy volunteers and depressed patients. After acute treatment the level of DCIM in plasma was low as compared to chronical treatment.

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Year:  1977        PMID： 403553     DOI： 10.1007/bf00426595

Source DB:  PubMed          Journal:  Psychopharmacology (Berl)        ISSN： 0033-3158            Impact factor:   4.530


  9 in total

1.  Determination of chlorimipramine and desmethylchlorimipramine in human plasma by ion-pair partition chromatography.

Authors: 
Journal:  J Chromatogr       Date:  1976-01-21

2.  Effect of antidepressant drugs on accumulation and disappearance of monoamines formed in vivo from labelled precursors in mouse brain.

Authors:  J Schubert; H Nybäck; G Sedvall
Journal:  J Pharm Pharmacol       Date:  1970-02       Impact factor: 3.765

3.  Clomipramine and amitriptyline in depressed outpatients. A controlled study.

Authors:  K Rickels; C C Weise; I Csanalosi; H R Chung; H S Feldman; H Rosenfeld; E M Whalen
Journal:  Psychopharmacologia       Date:  1974-02-06

4.  Synthesis and structure of an enaminic bis(trifluoroacetyl) derivatives of desipramine.

Authors:  T Walle; H Ehrsson; C Bogentoft; J Dolby
Journal:  Acta Pharm Suec       Date:  1972-12

5.  Effect of antidepressant drugs on the depletion of intraneuronal brain 5-hydroxytryptamine stores caused by 4-methyl-alpha-ethyl-meta-tyramine.

Authors:  A Carlsson; H Corrodi; K Fuxe; T Hökfelt
Journal:  Eur J Pharmacol       Date:  1969-03       Impact factor: 4.432

6.  Treatment of obsessional illnesses and phobic anxiety states with clomipramine.

Authors:  W K Marshall
Journal:  Br J Psychiatry       Date:  1971-10       Impact factor: 9.319

7.  Plasma levels of monomethylated tricyclic antidepressants during treatment with imipramine-like compounds.

Authors:  W Hammer; F Sjöqvist
Journal:  Life Sci       Date:  1967-09-01       Impact factor: 5.037

8.  Relationship between plasma level and therapeutic effect of nortriptyline.

Authors:  M Asberg; B Crönholm; F Sjöqvist; D Tuck
Journal:  Br Med J       Date:  1971-08-07

9.  Steady-state plasma levels of nortriptyline in twins: influence of genetic factors and drug therapy.

Authors:  B Alexanderson; D A Evans; F Sjöqvist
Journal:  Br Med J       Date:  1969-12-27
  9 in total
  2 in total

Review 1.  Clinical pharmacokinetics of clomipramine.

Authors:  A E Balant-Gorgia; M Gex-Fabry; L P Balant
Journal:  Clin Pharmacokinet       Date:  1991-06       Impact factor: 6.447

2.  Time course of plasma drug levels during once-daily oral administration of clomipramine.

Authors:  J E Burch; D M Shaw; A Michalakeas; B Karajgi; S G Roberts; M A Raddats
Journal:  Psychopharmacology (Berl)       Date:  1982       Impact factor: 4.530
  2 in total

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