| Literature DB >> 4034094 |
S Landas, J Fischer, L D Wilkin, L D Mitchell, A K Johnson, J W Turner, M Theriac, K C Moore.
Abstract
The brain of a 78-year-old woman with argyria was examined at autopsy. Silver nitrate deposition was observed in circumventricular organs (CVO) and in the paraventricular and supraoptic nuclei of the hypothalamus. These findings parallel animal experiments of other investigators and are the best demonstration so far of regional absence of the blood-brain barrier in humans. These observations demonstrate similarities between humans and other mammals of CVO anatomy, permeability to blood-borne agents, and perhaps neural connections between CVOs and magnocellular nuclei.Entities:
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Year: 1985 PMID： 4034094 DOI： 10.1016/0304-3940(85)90500-2
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046