Literature DB >> 4032601

A genetically determined murine model of infantile polycystic kidney disease.

J L Fry, W E Koch, J C Jennette, E McFarland, F A Fried, J Mandell.   

Abstract

We have evaluated a congenic strain of mice with congenital polycystic kidney disease in which the disease process appears to closely resemble human infantile polycystic kidney disease. Cysts formed first in the proximal tubules of the nephron and appeared, by light microscopy, to be preceded by vacuolization of the cells. These spaces, as seen by electron microscopy, occurred between adjacent cells. The pancreas was severely involved with reduction of both exocrine and endocrine elements. Cyst formation in the liver was minimal. Serum samples evaluated for urea nitrogen and creatinine were significantly elevated in affected mice. Serum glucose was within normal limits.

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Year:  1985        PMID： 4032601     DOI： 10.1016/s0022-5347(17)47448-9

Source DB:  PubMed          Journal:  J Urol        ISSN： 0022-5347            Impact factor:   7.450


  20 in total

1.  Validation of endogenous internal real-time PCR controls in renal tissues.

Authors:  Xiangqin Cui; Juling Zhou; Jing Qiu; Martin R Johnson; Michal Mrug
Journal:  Am J Nephrol       Date:  2009-09-01       Impact factor: 3.754

2.  Differential rescue of the renal and hepatic disease in an autosomal recessive polycystic kidney disease mouse mutant. A new model to study the liver lesion.

Authors:  B K Yoder; W G Richards; C Sommardahl; W E Sweeney; E J Michaud; J E Wilkinson; E D Avner; R P Woychik
Journal:  Am J Pathol       Date:  1997-06       Impact factor: 4.307

3.  Mutational analysis in 119 families with nephronophthisis.

Authors:  John F O'Toole; Edgar A Otto; Julia Hoefele; Juliana Helou; Friedhelm Hildebrandt
Journal:  Pediatr Nephrol       Date:  2006-10-24       Impact factor: 3.714

4.  Biliary dysgenesis in the PCK rat, an orthologous model of autosomal recessive polycystic kidney disease.

Authors:  Tatyana V Masyuk; Bing Q Huang; Anatoliy I Masyuk; Erik L Ritman; Vicente E Torres; Xiaofang Wang; Peter C Harris; Nicholas F Larusso
Journal:  Am J Pathol       Date:  2004-11       Impact factor: 4.307

5.  Cystin, a novel cilia-associated protein, is disrupted in the cpk mouse model of polycystic kidney disease.

Authors:  Xiaoying Hou; Michal Mrug; Bradley K Yoder; Elliot J Lefkowitz; Gabriel Kremmidiotis; Peter D'Eustachio; David R Beier; Lisa M Guay-Woodford
Journal:  J Clin Invest       Date:  2002-02       Impact factor: 14.808

6.  Immunolocalization of ion transport proteins in human autosomal dominant polycystic kidney epithelial cells.

Authors:  S R Brill; K E Ross; C J Davidow; M Ye; J J Grantham; M J Caplan
Journal:  Proc Natl Acad Sci U S A       Date:  1996-09-17       Impact factor: 11.205

7.  Hereditary polycystic kidney disease. Adult polycystic kidney disease associated with renal hypertension, renal osteodystrophy, and uremic enteritis in SPRD rats.

Authors:  J Kaspareit-Rittinghausen; F Deerberg; A Wcislo
Journal:  Am J Pathol       Date:  1991-09       Impact factor: 4.307

8.  Downregulation of Ke 6, a novel gene encoded within the major histocompatibility complex, in murine polycystic kidney disease.

Authors:  N Aziz; M M Maxwell; B St Jacques; B M Brenner
Journal:  Mol Cell Biol       Date:  1993-03       Impact factor: 4.272

9.  Renal and biliary abnormalities in a new murine model of autosomal recessive polycystic kidney disease.

Authors:  J Nauta; Y Ozawa; W E Sweeney; J C Rutledge; E D Avner
Journal:  Pediatr Nephrol       Date:  1993-04       Impact factor: 3.714

10.  Polycystic disease caused by deficiency in xylosyltransferase 2, an initiating enzyme of glycosaminoglycan biosynthesis.

Authors:  Eduard Condac; Robert Silasi-Mansat; Stanley Kosanke; Trenton Schoeb; Rheal Towner; Florea Lupu; Richard D Cummings; Myron E Hinsdale
Journal:  Proc Natl Acad Sci U S A       Date:  2007-05-21       Impact factor: 11.205
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