Literature DB >> 4032011

Muscle denervation increases the levels of two mRNAs coding for the acetylcholine receptor alpha-subunit.

D Goldman, J Boulter, S Heinemann, J Patrick.   

Abstract

The mRNA coding for the alpha-subunit of the acetylcholine receptor was studied in mouse leg and rat diaphragm muscle. We find that denervation of rat diaphragm results in a 7-fold increase in mRNA coding for the alpha-subunit, whereas denervation of mouse leg muscle results in approximately a 50-fold increase in alpha-subunit-specific mRNA. The relationship of the mRNAs purified from innervated and denervated muscle was investigated by SI nuclease mapping. Two mRNA species were found in both innervated and denervated muscle which differ in their 3'-untranslated region. The levels of both these mRNA species increase upon denervation of mouse leg muscle.

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Year:  1985        PMID： 4032011      PMCID： PMC6565325     

Source DB:  PubMed          Journal:  J Neurosci        ISSN： 0270-6474            Impact factor:   6.167


  30 in total

Review 1.  Nicotinic receptor-associated 43K protein and progressive stabilization of the postsynaptic membrane.

Authors:  J A Hill
Journal:  Mol Neurobiol       Date:  1992       Impact factor: 5.590

2.  Ubiquitin homeostasis is critical for synaptic development and function.

Authors:  Ping-Chung Chen; Bula J Bhattacharyya; John Hanna; Heather Minkel; Julie A Wilson; Daniel Finley; Richard J Miller; Scott M Wilson
Journal:  J Neurosci       Date:  2011-11-30       Impact factor: 6.167

3.  Alterations in neocortical expression of nicotinic acetylcholine receptor mRNAs following unilateral lesions of the rat nucleus basalis magnocellularis.

Authors:  I Miyai; S Ueno; S Yorifuji; H Fujimura; S Tarui
Journal:  J Neural Transm Gen Sect       Date:  1990

4.  Muscle acetylcholine receptor biosynthesis. Regulation by transcript availability.

Authors:  S Evans; D Goldman; S Heinemann; J Patrick
Journal:  J Biol Chem       Date:  1987-04-05       Impact factor: 5.157

Review 5.  Control of receptor sensitivity at the mRNA level.

Authors:  B J Morris
Journal:  Mol Neurobiol       Date:  1993 Fall-Winter       Impact factor: 5.590

6.  Mapping of brain areas expressing RNA homologous to two different acetylcholine receptor alpha-subunit cDNAs.

Authors:  D Goldman; D Simmons; L W Swanson; J Patrick; S Heinemann
Journal:  Proc Natl Acad Sci U S A       Date:  1986-06       Impact factor: 11.205

7.  Modulation of sodium-channel mRNA levels in rat skeletal muscle.

Authors:  S S Cooperman; S A Grubman; R L Barchi; R H Goodman; G Mandel
Journal:  Proc Natl Acad Sci U S A       Date:  1987-12       Impact factor: 11.205

Review 8.  Activity-dependent regulation of gene expression in muscle and neuronal cells.

Authors:  R Laufer; J P Changeux
Journal:  Mol Neurobiol       Date:  1989 Spring-Summer       Impact factor: 5.590

9.  cAMP stimulation of acetylcholine receptor expression is mediated through posttranslational mechanisms.

Authors:  W N Green; A F Ross; T Claudio
Journal:  Proc Natl Acad Sci U S A       Date:  1991-02-01       Impact factor: 11.205

10.  Coordinate regulation of RNAs encoding two isoforms of the rat muscle nicotinic acetylcholine receptor beta-subunit.

Authors:  D Goldman; K Tamai
Journal:  Nucleic Acids Res       Date:  1989-04-25       Impact factor: 16.971
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