Literature DB >> 4031875

Effect of unilateral decortication on choline acetyltransferase activity in the nucleus basalis and other areas of the rat brain.

P H Stephens, A C Cuello, M V Sofroniew, R C Pearson, P Tagari.   

Abstract

Acetyl-coenzyme A: choline O-acetyltransferase (EC 2.3.1.6) (ChAT) enzyme activity was measured in the nucleus basalis and other microscopically identified brain areas at various times after unilateral cortical lesions were made in the rat. Initially, a significant decrease in ChAT activity was detected in the nucleus basalis ipsilateral to the lesion. However, after 120 days ChAT activity had apparently recovered, as levels of the enzyme at that time were not significantly different from control values. No changes in ChAT activity could be detected in any of the other brain areas similarly studied. The significance of these findings and their relationship to the morphological changes seen in neurones of the nucleus basalis after cortical lesions are discussed.

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Year:  1985        PMID： 4031875     DOI： 10.1111/j.1471-4159.1985.tb05517.x

Source DB:  PubMed          Journal:  J Neurochem        ISSN： 0022-3042            Impact factor:   5.372


  8 in total

1.  Nucleus basalis lesions attenuate acquisition, but not retention, of Pavlovian heart rate conditioning and have no effect on eyeblink conditioning.

Authors:  S R Ginn; D A Powell
Journal:  Exp Brain Res       Date:  1992       Impact factor: 1.972

Review 2.  Experimental neurotrophic factor therapy leads to cortical synaptic remodeling and compensates for behavioral deficits.

Authors:  A C Cuello
Journal:  J Psychiatry Neurosci       Date:  1997-01       Impact factor: 6.186

3.  Nerve growth factor-induced synaptogenesis and hypertrophy of cortical cholinergic terminals.

Authors:  L Garofalo; A Ribeiro-da-Silva; A C Cuello
Journal:  Proc Natl Acad Sci U S A       Date:  1992-04-01       Impact factor: 11.205

4.  Ethylcholine mustard aziridinium ion lesions of the rat cortex result in retrograde degeneration of basal forebrain cholinergic neurons: implications for animal models of neurodegenerative disease.

Authors:  P H Stephens; P Tagari; A C Cuello
Journal:  Neurochem Res       Date:  1987-07       Impact factor: 3.996

5.  Hemicholinium mustard derivatives: preliminary assessment of cholinergic neurotoxicity.

Authors:  P C Tagari; D Maysinger; A C Cuello
Journal:  Neurochem Res       Date:  1986-07       Impact factor: 3.996

6.  Gangliosides potentiate in vivo and in vitro effects of nerve growth factor on central cholinergic neurons.

Authors:  A C Cuello; L Garofalo; R L Kenigsberg; D Maysinger
Journal:  Proc Natl Acad Sci U S A       Date:  1989-03       Impact factor: 11.205

Review 7.  Trophic factor effects on cholinergic innervation in the cerebral cortex of the adult rat brain.

Authors:  A C Cuello; D Maysinger; L Garofalo
Journal:  Mol Neurobiol       Date:  1992       Impact factor: 5.590

8.  The human brain NGF metabolic pathway is impaired in the pre-clinical and clinical continuum of Alzheimers disease.

Authors:  Rowan Pentz; M Florencia Iulita; Adriana Ducatenzeiler; David A Bennett; A Claudio Cuello
Journal:  Mol Psychiatry       Date:  2020-06-02       Impact factor: 15.992
  8 in total

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