| Literature DB >> 4030550 |
M Chung, E Radwanski, D Loebenberg, C C Lin, E Oden, S Symchowicz, R P Gural, G H Miller.
Abstract
Pharmacokinetic parameters of Sch 34343 have been determined for mice, rats, rabbits, monkeys, dogs and humans and correlated among species as an exponential function of body weight. The pertinent pharmacokinetic parameters tested are apparent and steady-state volumes of distribution, total body clearance, elimination phase half-life, and mean residence time. This study showed that the extrapolation of animal data to humans on a new investigational drug, Sch 34343, can be potentially useful.Entities:
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Year: 1985 PMID： 4030550 DOI： 10.1093/jac/15.suppl_c.227
Source DB: PubMed Journal: J Antimicrob Chemother ISSN： 0305-7453 Impact factor: 5.790