Literature DB >> 4030499

New antitumor antibiotics, FR-900405 and FR-900406. II. Production, isolation, characterization and antitumor activity.

S Kiyoto, M Nishikawa, H Terano, M Kohsaka, H Aoki, H Imanaka, Y Kawai, I Uchida, M Hashimoto.   

Abstract

The new antitumor antibiotics, FR-900405 and FR-900406, were isolated from the culture broth of Actinomadura pulveracea sp. nov. No. 6049. These compounds which contain sulfur in the molecule, represent a novel class of antitumor agents. FR-900405 and FR-900406 are highly active in mice against experimental tumors and exhibit antimicrobial activity against Gram-positive and Gram-negative bacteria and fungi.

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Year:  1985        PMID: 4030499     DOI: 10.7164/antibiotics.38.840

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN: 0021-8820            Impact factor:   2.649


  2 in total

1.  Mode of action of C-1027, a new macromolecular antitumor antibiotic with highly potent cytotoxicity, on human hepatoma BEL-7402 cells.

Authors:  Y J Xu; D D Li; Y S Zhen
Journal:  Cancer Chemother Pharmacol       Date:  1990       Impact factor: 3.333

2.  Esperamicins, a class of potent antitumor antibiotics: mechanism of action.

Authors:  B H Long; J Golik; S Forenza; B Ward; R Rehfuss; J C Dabrowiak; J J Catino; S T Musial; K W Brookshire; T W Doyle
Journal:  Proc Natl Acad Sci U S A       Date:  1989-01       Impact factor: 11.205

  2 in total

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