| Literature DB >> 4029813 |
Abstract
The effects of gefarnate on several acute gastric lesions were studied in rats. Gefarnate, given at either 100 approximately 1000 mg/kg orally or intraduodenally, dose-dependently inhibited the formation of gastric lesions induced by HCl-ethanol, HCl-taurocholate and aspirin. Cimetidine, given at 30 approximately 100 mg/kg as a reference drug, also significantly inhibited both HCl-ethanol and aspirin-induced lesions. The present study suggests that gefarnate, as well as cimetidine, is useful for the treatment of acute gastric lesions in man.Entities:
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Year: 1985 PMID： 4029813 DOI： 10.1254/fpj.85.443
Source DB: PubMed Journal: Nihon Yakurigaku Zasshi ISSN： 0015-5691