Literature DB >> 402936

Heavy-chain variable-region sequence from an inulin-binding myeloma protein.

M Vrana, S Rudikoff, M Potter.   

Abstract

The entire variable-region sequence of the heavy chain from ABE-47N, a BALB/c inulin-binding myeloma protein, has been determined. This protein is unusual in that the third complementarity region (H3) is extremely short, consisting of at the most three and probably only one amino acid. A comparison of the heavy-chain hypervariable regions from mouse, human, and rabbit proteins shows that the variability in length of H3 is greater than that seen in the first or second hypervariable regions. This variability in H3 length suggests a specialized function for this region.

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Year:  1977        PMID： 402936     DOI： 10.1021/bi00625a022

Source DB:  PubMed          Journal:  Biochemistry        ISSN： 0006-2960            Impact factor:   3.162


  4 in total

1.  Sequence variation among heavy chains from inulin-binding myeloma proteins.

Authors:  M Vrana; S Rudikoff; M Potter
Journal:  Proc Natl Acad Sci U S A       Date:  1978-04       Impact factor: 11.205

2.  Variable region genes for the immunoglobulin framework are assembled from small segments of DNA--a hypothesis.

Authors:  E A Kabat; T T Wu; H Bilofsky
Journal:  Proc Natl Acad Sci U S A       Date:  1978-05       Impact factor: 11.205

3.  Structural evidence for independent joining region gene in immunoglobulin heavy chains from anti-galactan myeloma proteins and its potential role in generating diversity in complementarity-determining regions.

Authors:  D N Rao; S Rudikoff; H Krutzsch; M Potter
Journal:  Proc Natl Acad Sci U S A       Date:  1979-06       Impact factor: 11.205

4.  Anti-inulin [beta-(2 leads to 1)-linked polyfructose] and anti-grass levan [beta-(2 leads to 6)-linked polyfructose] antibody response in mice.

Authors:  C C Chien
Journal:  Infect Immun       Date:  1980-03       Impact factor: 3.441
  4 in total

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