Dendritic alterations in chronic animals with experimental neurofibrillary changes.

Dendritic changes were quantitated in the cerebral cortex and subiculum of rabbits injected with aluminum tartrate for 90 days (5 days/week) at 100, 200, and 300 days after the last injection of aluminum. Both apical and basal dendrites of the cerebral cortex and subiculum responded similarly to aluminum tartrate. The dendrites were fewer and shorter in the animals examined at 200 and 300 days postinjection of aluminum tartrate. Such dendritic changes were more prominent at longer postinjection times and in dendrites that were more peripheral from the cell body. Aluminum-induced changes in apical dendrites were more prominent in the subiculum than in the cerebral cortex. Aluminum-induced changes in basal dendrites, however, were more prominent in the cerebral cortex than in the subiculum. The results suggest a time delay between the initial accumulation of neurofibrillary changes and the subsequent loss of peripheral dendritic branches, which appears to be long-lasting.