Literature DB >> 4029020

Lung tissue penetration of temocillin.

W Cowan, A Baird, J D Sleigh, J M Gray, J M Leiper, D H Lawson.   

Abstract

Eight patients about to have the whole or part of a lung resected were given a 2g bolus dose of temocillin. A series of serum samples and a piece of peripheral lung tissue were collected and assayed for temocillin concentration. 30 minutes after drug administration, the mean serum and tissue concentrations were 172 mg/L and 45 mg/kg respectively.

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Year:  1985        PMID: 4029020     DOI: 10.2165/00003495-198500295-00031

Source DB:  PubMed          Journal:  Drugs        ISSN: 0012-6667            Impact factor:   9.546


  4 in total

1.  Temocillin, in-vitro activity and the pharmacokinetics and tissue penetration in healthy volunteers.

Authors:  R M Brown; R Wise; J M Andrews
Journal:  J Antimicrob Chemother       Date:  1982-10       Impact factor: 5.790

2.  BRL 17421, a novel beta-lactam antibiotic, highly resistant to beta-lactamases, giving high and prolonged serum levels in humans.

Authors:  B Slocombe; M J Basker; P H Bentley; J P Clayton; M Cole; K R Comber; R A Dixon; R A Edmondson; D Jackson; D J Merrikin; R Sutherland
Journal:  Antimicrob Agents Chemother       Date:  1981-07       Impact factor: 5.191

3.  Temocillin (BRL 17421): in-vitro antibacterial activity and susceptibility to beta-lactamases.

Authors:  I Phillips; A King; K Shannon; C Warren
Journal:  J Antimicrob Chemother       Date:  1982-10       Impact factor: 5.790

4.  Temocillin concentrations in human tissues.

Authors:  J G Gould; G Meikle; D L Cooper; R Horton
Journal:  Drugs       Date:  1985       Impact factor: 9.546

  4 in total
  1 in total

Review 1.  Pharmacokinetics and Pharmacodynamics of Temocillin.

Authors:  Kevin Alexandre; Bruno Fantin
Journal:  Clin Pharmacokinet       Date:  2018-03       Impact factor: 6.447

  1 in total

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