Literature DB >> 4027512

Atropine blockade of nerve-mediated stimulation of the human detrusor.

R B Kinder, A R Mundy.   

Abstract

The effect of atropine on the isometric contractile response of isolated human detrusor muscle strips to electrical field stimulation has been studied. A 94.1% reduction in the response in the presence of tetrodotoxin demonstrated the neuronal nature of the stimulus. Atropine caused a 92.7% inhibition of the response. It was concluded that the nerve-mediated stimulus in human detrusor is cholinergic in nature and that "atropine resistance" does not occur in man.

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Year:  1985        PMID： 4027512     DOI： 10.1111/j.1464-410x.1985.tb06301.x

Source DB:  PubMed          Journal:  Br J Urol        ISSN： 0007-1331


  12 in total

1.  P2X receptor expression in mouse urinary bladder and the requirement of P2X(1) receptors for functional P2X receptor responses in the mouse urinary bladder smooth muscle.

Authors:  C Vial; R J Evans
Journal:  Br J Pharmacol       Date:  2000-12       Impact factor: 8.739

Review 2.  Effects of pinacidil on bladder muscle.

Authors:  K E Andersson; P O Andersson; M Fovaeus; H Hedlund; A Malmgren; C Sjögren
Journal:  Drugs       Date:  1988       Impact factor: 9.546

3.  Isolation and individual electrical stimulation of single smooth-muscle cells from the urinary bladder of the pig.

Authors:  J J Glerum; R van Mastrigt; J C Romijn; D J Griffiths
Journal:  J Muscle Res Cell Motil       Date:  1987-04       Impact factor: 2.698

4.  Inhibitory effect of streptozotocin-induced diabetes on non-cholinergic motor transmission in rat detrusor and its prevention by sorbinil.

Authors:  G N Luheshi; M A Zar
Journal:  Br J Pharmacol       Date:  1990-10       Impact factor: 8.739

5.  Partial mediation by nitric oxide of the relaxation of human isolated detrusor strips in response to electrical field stimulation.

Authors:  M J James; A T Birmingham; S J Hill
Journal:  Br J Clin Pharmacol       Date:  1993-04       Impact factor: 4.335

6.  The effect of in vivo oestrogen pretreatment on the contractile response of rat isolated detrusor muscle.

Authors:  R A Elliott; C M Castleden; A Miodrag
Journal:  Br J Pharmacol       Date:  1992-11       Impact factor: 8.739

7.  The direct effects of diethylstilboestrol and nifedipine on the contractile responses of isolated human and rat detrusor muscles.

Authors:  R A Elliott; C M Castleden; A Miodrag; P Kirwan
Journal:  Eur J Clin Pharmacol       Date:  1992       Impact factor: 2.953

Review 8.  Current concepts in the treatment of disorders of micturition.

Authors:  K E Andersson
Journal:  Drugs       Date:  1988-04       Impact factor: 9.546

Review 9.  Purinergic signalling in the urinary tract in health and disease.

Authors:  Geoffrey Burnstock
Journal:  Purinergic Signal       Date:  2013-11-22       Impact factor: 3.765

Review 10.  Purinoceptors as therapeutic targets for lower urinary tract dysfunction.

Authors:  Anthony P D W Ford; Joel R Gever; Philip A Nunn; Yu Zhong; Joseph S Cefalu; Michael P Dillon; Debra A Cockayne
Journal:  Br J Pharmacol       Date:  2006-02       Impact factor: 8.739
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