Literature DB >> 4027173

Rapid induction of cirrhosis by administration of carbon tetrachloride plus phospholipase D.

T Ozeki, K Funakoshi, K Iwaki.   

Abstract

A new and rapid method for the production of liver cirrhosis in the rat is described. Rats were treated with carbon tetrachloride for 4 weeks and then injected i.p. with phospholipase D daily for 6 days. Controls received either carbon tetrachloride or phospholipase D only. Following the combined treatment cirrhosis developed rapidly; the liver developed micronodules and severe cirrhosis was accompanied by ascites and splenomegaly.

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Year:  1985        PMID： 4027173      PMCID： PMC2041087     

Source DB:  PubMed          Journal:  Br J Exp Pathol        ISSN： 0007-1021


  6 in total

Review 1.  Phospholipase D.

Authors:  M Heller
Journal:  Adv Lipid Res       Date:  1978

2.  The effects of partial hepatectomy on portal pressure in rats.

Authors:  R H Oliver; P M Sutton
Journal:  Br J Surg       Date:  1966-02       Impact factor: 6.939

3.  Instant cirrhosis. An improved method for producing cirrhosis of the liver in rats by simultaneous administration of carbon tetrachloride and phenobarbitone.

Authors:  E K McLean; A E McLean; P M Sutton
Journal:  Br J Exp Pathol       Date:  1969-10

4.  Phospholipase D from savoy cabbage: purification and preliminary kinetic characterization.

Authors:  T T Allgyer; M A Wells
Journal:  Biochemistry       Date:  1979-11-27       Impact factor: 3.162

5.  Microsomal phospholipase D of rat brain and lung tissues.

Authors:  R J Chalifour; J N Kanfer
Journal:  Biochem Biophys Res Commun       Date:  1980-09-30       Impact factor: 3.575

6.  Specificity of lysophospholipase D.

Authors:  R L Wykle; W F Kraemer; J M Schremmer
Journal:  Biochim Biophys Acta       Date:  1980-07-14
  6 in total

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