Literature DB >> 4026856

Dexamethasone directly inhibits snake venom phospholipase A.

N Kato, K M Halprin, S Matsuo, J R Taylor.   

Abstract

Dexamethasone was found to directly inhibit snake venom phospholipase A2 within 3 to 10 minutes. To detect this effect, the incubation time seems to be critical. Moreover, the inhibitory effect of dexamethasone and mepacrine were additive with each other. We speculate that this direct inhibitory effect on phospholipase A2 plays a part in its strong biological activity.

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Year:  1985        PMID： 4026856     DOI： 10.1016/0006-291x(85)90481-4

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  3 in total

1.  Protective effect of a new hypothalamic peptide against cobra venom and trauma-induced neuronal injury.

Authors:  A A Galoyan; J S Sarkissian; T K Kipriyan; E J Sarkissian; E A Chavushyan; R M Sulkhanyan; I B Meliksetyan; S S Abrahamyan; Z A Avetisyan; N A Otieva
Journal:  Neurochem Res       Date:  2001-09       Impact factor: 3.996

2.  Comparison of the protection against neuronal injury by hypothalamic peptides and by dexamethasone.

Authors:  A A Galoyan; J S Sarkissian; T K Kipriyan; E J Sarkissian; Y K Grigorian; R M Sulkhanyan; T S Khachatrian
Journal:  Neurochem Res       Date:  2000-12       Impact factor: 3.996

3.  Potential therapeutic efficacy of inhibitors of human phospholipase A2 in septic shock.

Authors:  P Vadas; E Stefanski; W Pruzanski
Journal:  Agents Actions       Date:  1986-11
  3 in total

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