Literature DB >> 402685

A potent antinociceptive cannabinoid which lacks opiate substitution properties in monkeys.

B R Martin, W L Dewey, M D Aceto, M D Adams, J T Earnhardt, J M Carney.   

Abstract

(-)-9-Nor-9beta-hydroxy-hexahydrocannabinol[(-)-9-nor-9beta-OH-HHC] produced hypotension and bradycardia in anesthetized dogs, was a potent antinociceptive agent in the mouse tail-flick and p-phenylquinone abdominal-stretching tests, but did not reverse the effects of morphine withdrawal in dependent monkeys.

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Year:  1977        PMID: 402685

Source DB:  PubMed          Journal:  Res Commun Chem Pathol Pharmacol        ISSN: 0034-5164


  1 in total

Review 1.  Toward drugs derived from cannabis.

Authors:  R Mechoulam; E A Carlini
Journal:  Naturwissenschaften       Date:  1978-04
  1 in total

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