Literature DB >> 4026832

Inositol-1,4,5-trisphosphate releases calcium from skinned cultured smooth muscle cells.

H Yamamoto, C van Breemen.   

Abstract

We examined the effects of inositol-1,4,5-trisphosphate on 45Ca uptake and 45Ca efflux in the saponin skinned primary cultured rat aortic smooth muscle cells. 10 microM inositol-1,4,5-trisphosphate induced a rapid (half time less than 10 sec) and large quantity of Ca release in both 45Ca uptake and 45Ca efflux in the skinned cells preloaded with 1 microM free Ca. Dose response curves showed that 100 microM inositol-1,4,5-trisphosphate produced a maximal Ca release of 97.3% of the MgATP dependent 45Ca uptake or 289 mumoles/liter cells, which was much greater than the maximal caffeine induced Ca release and would be sufficient to produce maximal tension.

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Year:  1985        PMID： 4026832     DOI： 10.1016/0006-291x(85)90412-7

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  23 in total

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6.  Endothelium-derived relaxing factor inhibits the formation of inositol trisphosphate by rabbit aorta.

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7.  Effects of inositol phosphates on the membrane activity of smooth muscle cells of the rabbit portal vein.

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8.  Calcium release induced by inositol 1,4,5-trisphosphate in single rabbit intestinal smooth muscle cells.

Authors:  S Komori; T B Bolton
Journal:  J Physiol       Date:  1991-02       Impact factor: 5.182

9.  Heparin specifically inhibits the inositol 1,4,5-trisphosphate-induced Ca2+ release from skinned rat aortic smooth muscle cells in primary culture.

Authors:  H Yamamoto; H Kanaide; M Nakamura
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1990-04       Impact factor: 3.000

10.  Early events in inositol phosphate metabolism in longitudinal smooth muscle from guinea-pig intestine stimulated with carbachol.

Authors:  D M Salmon; T B Bolton
Journal:  Biochem J       Date:  1988-09-01       Impact factor: 3.857
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