Literature DB >> 4026809

High concentrations of aldehydes slow the reaction of cytoplasmic aldehyde dehydrogenase with thiol-group modifiers.

T M Kitson.   

Abstract

High concentrations of aldehydes slow the inactivation of cytoplasmic aldehyde dehydrogenase by disulfiram and also slow the reaction of the enzyme with 2,2'-dithiodipyridine. It is concluded that a low-affinity aldehyde-binding site is probably the site at which thiol-group modifiers react with aldehyde dehydrogenase, as well as being the active site for hydrolysis of 4-nitrophenyl acetate.

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Year:  1985        PMID： 4026809      PMCID： PMC1145050          DOI： 10.1042/bj2280765

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  7 in total

1.  Kinetic studies on the esterase activity of cytoplasmic sheep liver aldehyde dehydrogenase.

Authors:  A K MacGibbon; S J Haylock; P D Buckley; L F Blackwell
Journal:  Biochem J       Date:  1978-06-01       Impact factor: 3.857

2.  Methyltetrazolethiol and the Antabuse reaction.

Authors:  T M Kitson
Journal:  Lancet       Date:  1984-12-08       Impact factor: 79.321

3.  Relationship between the mechanisms of the esterase and dehydrogenase activities of the cytoplasmic aldehyde dehydrogenase from sheep liver. An alternative view.

Authors:  L F Blackwell; A F Bennett; P D Buckley
Journal:  Biochemistry       Date:  1983-08-02       Impact factor: 3.162

4.  Further studies of the action of disulfiram and 2,2'-dithiodipyridine on the dehydrogenase and esterase activities of sheep liver cytoplasmic aldehyde dehydrogenase.

Authors:  T M Kitson
Journal:  Biochem J       Date:  1982-06-01       Impact factor: 3.857

5.  The use of pH-gradient ion-exchange chromatography to separate sheep liver cytoplasmic aldehyde dehydrogenase from mitochondrial enzyme contamination, and observations on the interaction between the pure cytoplasmic enzyme and disulfiram.

Authors:  F M Dickinson; G J Hart; T M Kitson
Journal:  Biochem J       Date:  1981-12-01       Impact factor: 3.857

6.  The activation of aldehyde dehydrogenase by diethylstilboestrol and 2,2'-dithiodipyridine.

Authors:  T M Kitson
Journal:  Biochem J       Date:  1982-10-01       Impact factor: 3.857

7.  The time course of the interaction of sheep liver cytoplasmic aldehyde dehydrogenase with 2,2'- and 4,4'-dithiodipyridine: a comparison with the action of disulfiram.

Authors:  T M Kitson
Journal:  Arch Biochem Biophys       Date:  1984-11-01       Impact factor: 4.013
  7 in total
  5 in total

Review 1.  In-depth understanding of molecular mechanisms of aldehyde toxicity to engineer robust Saccharomyces cerevisiae.

Authors:  Lahiru N Jayakody; Yong-Su Jin
Journal:  Appl Microbiol Biotechnol       Date:  2021-03-20       Impact factor: 4.813

2.  Studies on the mechanism of sheep liver cytosolic aldehyde dehydrogenase. The effect of pH on the aldehyde binding reactions and a re-examination of the problem of the site of proton release in the mechanism.

Authors:  F M Dickinson
Journal:  Biochem J       Date:  1986-08-15       Impact factor: 3.857

3.  Studies of the esterase activity of cytosolic aldehyde dehydrogenase with resorufin acetate as substrate.

Authors:  T M Kitson; K E Kitson
Journal:  Biochem J       Date:  1997-03-15       Impact factor: 3.857

4.  Effect of some thiocarbamate compounds on aldehyde dehydrogenase and implications for the disulfiram ethanol reaction.

Authors:  T M Kitson
Journal:  Biochem J       Date:  1991-08-15       Impact factor: 3.857

5.  The effects of Mg2+ on certain steps in the mechanisms of the dehydrogenase and esterase reactions catalysed by sheep liver aldehyde dehydrogenase. Support for the view that dehydrogenase and esterase activities occur at the same site on the enzyme.

Authors:  F M Dickinson; G W Haywood
Journal:  Biochem J       Date:  1986-02-01       Impact factor: 3.857
  5 in total

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