| Literature DB >> 4026479 |
H Blom, J Stolk, H B Schreuder, M von Blomberg-van der Flier.
Abstract
A patient is described with cholestatic hepatitis following the use of carbimazole. A liver biopsy specimen showed intracanalicular cholestasis and some mononuclear cell infiltrate in the portal triades, consistent with drug toxicity; indications of an autoimmune or viral pathogenesis were absent. Rechallenge with the drug precipitated jaundice and disturbed liver function once more. Carbimazole induced a blastogenic response of patient lymphocytes in vitro. Both may suggest the involvement of an immune-mediated reaction, especially as it has been shown that sensitized lymphocytes may produce a cholestatic factor on stimulation with antigen.Entities:
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Year: 1985 PMID： 4026479
Source DB: PubMed Journal: Arch Intern Med ISSN： 0003-9926