Pharmacokinetics of the third-generation cephalosporins.

The pharmacokinetics of 10 of the newer, third-generation cephalosporins are reviewed. Important features are tabulated. Generalizations are made about structure-activity relationships, relationships between kinetic features, minimal inhibitory concentrations, dosage regimens, and tissue penetration. Tissue levels of ceftazidime are given as examples. These newer chemotherapeutic agents do not possess unique pharmacokinetic properties, but a combination of high antimicrobial activity, safety, and straightforward kinetics facilitates their use in a number of different clinical settings.