Literature DB >> 4021730

First pass metabolism of ethanol--a gastrointestinal barrier against the systemic toxicity of ethanol.

R J Julkunen, C Di Padova, C S Lieber.   

Abstract

Both in men and rats, most of the ethanol ingested at a low dose is metabolized before it reaches the systemic circulation. Oxidation of ethanol (mainly in the stomach) accounts for the bulk of this effect. This "first pass" metabolism (FPM) may be viewed as a barrier which protects against the systemic toxicity of ethanol. This barrier can be overcome by large doses of ethanol. Its efficiency is also reduced by a decrease in gastric alcohol dehydrogenase (ADH) activity secondary to chronic alcohol consumption.

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Year:  1985        PMID： 4021730     DOI： 10.1016/0024-3205(85)90470-9

Source DB:  PubMed          Journal:  Life Sci        ISSN： 0024-3205            Impact factor:   5.037


  20 in total

1.  Effects of H2-receptor antagonists on gastric alcohol dehydrogenase activity.

Authors:  J Caballería; E Baraona; R Deulofeu; R Hernández-Muñoz; J Rodés; C S Lieber
Journal:  Dig Dis Sci       Date:  1991-12       Impact factor: 3.199

2.  Chronic ethanol administration depresses fatty acid synthesis in rat adipose tissue.

Authors:  J S Wilson; M A Korsten; L P Donnelly; P W Colley; J B Somer; R C Pirola
Journal:  Biochem J       Date:  1988-04-15       Impact factor: 3.857

3.  The activity of class I, III, and IV of alcohol dehydrogenase isoenzymes and aldehyde dehydrogenase in gastric cancer.

Authors:  Wojciech Jelski; Lech Chrostek; Maciej Szmitkowski
Journal:  Dig Dis Sci       Date:  2007-01-09       Impact factor: 3.199

4.  Effect of omeprazole on gastric first-pass metabolism of ethanol.

Authors:  R Roine; R Hernández-Muñoz; E Baraona; R Greenstein; C S Lieber
Journal:  Dig Dis Sci       Date:  1992-06       Impact factor: 3.199

5.  First-pass metabolism of alcohol. Absence of diurnal variation and its inhibition by cimetidine after evening meal.

Authors:  R Sharma; R T Gentry; R T Lim; C S Lieber
Journal:  Dig Dis Sci       Date:  1995-10       Impact factor: 3.199

Review 6.  Clinical pharmacokinetics of ethanol.

Authors:  N H Holford
Journal:  Clin Pharmacokinet       Date:  1987-11       Impact factor: 6.447

7.  Lactic acid bacteria prevent alcohol-induced steatohepatitis in rats by acting on the pathways of alcohol metabolism.

Authors:  Liu Qing; Tailing Wang
Journal:  Clin Exp Med       Date:  2008-09-24       Impact factor: 3.984

Review 8.  Extrahepatic metabolism of drugs in humans.

Authors:  D R Krishna; U Klotz
Journal:  Clin Pharmacokinet       Date:  1994-02       Impact factor: 6.447

9.  Inhibition of gastric alcohol dehydrogenase activity by histamine H2-receptor antagonists has no influence on the pharmacokinetics of ethanol after a moderate dose.

Authors:  A Mallat; F Roudot-Thoraval; J F Bergmann; H Trout; G Simonneau; C Dutreuil; L E Blanc; D Dhumeaux; J C Delchier
Journal:  Br J Clin Pharmacol       Date:  1994-02       Impact factor: 4.335

Review 10.  H2-antagonists and alcohol. Do they interact?

Authors:  R Gugler
Journal:  Drug Saf       Date:  1994-04       Impact factor: 5.606
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