Literature DB >> 4020835

Synthesis and antineoplastic evaluations of 5,8-bis[(aminoalkyl)amino]-1-azaanthracene-9,10-diones.

A P Krapcho, J J Landi, M P Hacker, J J McCormack.   

Abstract

Several 5,8-bis[(aminoalkyl)amino]-1-azaanthracene-9,10-diones have been synthesized and evaluated for antitumor activity against L1210 leukemia both in vitro and in vivo. Comparisons are made to the corresponding carbocyclic analogues. One of the aza analogues showed modest in vivo activity.

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Year:  1985        PMID: 4020835     DOI: 10.1021/jm00146a029

Source DB:  PubMed          Journal:  J Med Chem        ISSN: 0022-2623            Impact factor:   7.446


  3 in total

1.  Synthesis and antitumor evaluation of 6-aryl-substituted benzo[j]phenanthridine- and benzo[g]pyrimido[4,5-c]isoquinolinequinones.

Authors:  Jennyfer Iribarra; David Vásquez; Cristina Theoduloz; Julio Benites; David Ríos; Jaime A Valderrama
Journal:  Molecules       Date:  2012-09-28       Impact factor: 4.411

2.  One Pot and Metal-Free Approach to 3-(2-Hydroxybenzoyl)-1-aza-anthraquinones.

Authors:  Jiaqi Yuan; Qian He; Shanshan Song; Xiaofei Zhang; Zehong Miao; Chunhao Yang
Journal:  Molecules       Date:  2019-08-20       Impact factor: 4.411

3.  Pixantrone can be activated by formaldehyde to generate a potent DNA adduct forming agent.

Authors:  Ben J Evison; Oula C Mansour; Ernesto Menta; Don R Phillips; Suzanne M Cutts
Journal:  Nucleic Acids Res       Date:  2007-05-05       Impact factor: 16.971

  3 in total

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