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Literature DB >> 4020699

Hypothalamic thermosensitivity in capsaicin-desensitized rats.

M Cormarèche-Leydier, S G Shimada, J T Stitt.

Abstract

In rats, we tested the hypothesis that capsaicin desensitization reduces hypothalamic warm thermosensitivity. We locally heated and cooled the hypothalamus using water-perfused thermodes while observing thermoregulatory variables. In untreated rats, a small dose of capsaicin had profound effects on thermoregulation. However, desensitizing rats to capsaicin had no effect on hypothalamic thermosensitivity for metabolic rate or changes in body temperature due to displacements of hypothalamic temperature. Contrary to current opinion, we conclude that capsaicin desensitization does not alter hypothalamic thermosensitivity to warm or cold.

Entities: Chemical Disease Species

Mesh：

Substances：
Capsaicin

Year: 1985 PMID： 4020699 PMCID： PMC1192925 DOI： 10.1113/jphysiol.1985.sp015706

Source DB: PubMed Journal: J Physiol ISSN： 0022-3751 Impact factor: 5.182

23 in total

1. ROLE OF THE PULMONARY ARTERIAL BARORECEPTORS IN THE EFFECTS PRODUCED BY CAPSAICIN IN THE DOG.

Authors: H M COLERIDGE; J C COLERIDGE; C KIDD
Journal: J Physiol Date: 1964-03 Impact factor: 5.182

2. The regulation of respiratory evaporative heat loss in the rabbit.

Authors: J T Stitt
Journal: J Physiol Date: 1976-06 Impact factor: 5.182

3. Mitochondrial changes in preoptic neurons after capsaicin desensitization of the hypothalamic thermodetectors in rats.

Authors: J Szolcsányi; F Joó; A Jancsó-Gábor
Journal: Nature Date: 1971-01-08 Impact factor: 49.962

Hypothalamic thermosensitivity in capsaicin-desensitized rats.

1. ROLE OF THE PULMONARY ARTERIAL BARORECEPTORS IN THE EFFECTS PRODUCED BY CAPSAICIN IN THE DOG.

2. The regulation of respiratory evaporative heat loss in the rabbit.

3. Mitochondrial changes in preoptic neurons after capsaicin desensitization of the hypothalamic thermodetectors in rats.

4. Cardiovascular effects of capsaicin in dogs and rabbits.

5. Vascular responses to stimulation of receptors in muscle by capsaicin.

6. The effect of capsaïcin on temperature regulation of the rat.

7. Substance P release from spinal cord slices by capsaicin.

8. Pharmacologically induced selective degeneration of chemosensitive primary sensory neurones.

9. Stimulation and desensitization of the hypothalamic heat-sensitive structures by capsaicin in rats.

10. Hypothalamic thermo-responsive neurones in the new-born rat.

1. Hypoxia reduces the hypothalamic thermogenic threshold and thermosensitivity.

2. A study of the mechanism of action of the mild analgesic dipyrone.