Literature DB >> 4020657

Effect of fatty acids and alcohols on the penetration of acyclovir across human skin in vitro.

E R Cooper, E W Merritt, R L Smith.   

Abstract

The cutaneous penetration of acyclovir can be significantly increased from a propylene glycol base vehicle by adding small amounts of a polar lipid such as oleic acid. These results are consistent with those found for salicylic acid, and the large increases in acyclovir penetration could potentially lead to better topical treatment of herpes simplex.

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Year:  1985        PMID: 4020657     DOI: 10.1002/jps.2600740623

Source DB:  PubMed          Journal:  J Pharm Sci        ISSN: 0022-3549            Impact factor:   3.534


  11 in total

1.  Percutaneous absorption-enhancing activity of urea derivatives.

Authors:  S K Han; Y H Jun; Y J Rho; S C Hong; Y M Kim
Journal:  Arch Pharm Res       Date:  1991-03       Impact factor: 4.946

2.  Contributions of drug solubilization, partitioning, barrier disruption, and solvent permeation to the enhancement of skin permeation of various compounds with fatty acids and amines.

Authors:  B J Aungst; J A Blake; M A Hussain
Journal:  Pharm Res       Date:  1990-07       Impact factor: 4.200

3.  Bile salt-fatty acid mixed micelles as nasal absorption promoters. III. Effects on nasal transport and enzymatic degradation of acyclovir prodrugs.

Authors:  Z Shao; A K Mitra
Journal:  Pharm Res       Date:  1994-02       Impact factor: 4.200

4.  In vitro enhancement of lactate esters on the percutaneous penetration of drugs with different lipophilicity.

Authors:  Jianhua Zhang; Mei Liu; Hongjian Jin; Liandong Deng; Jinfeng Xing; Anjie Dong
Journal:  AAPS PharmSciTech       Date:  2010-05-22       Impact factor: 3.246

5.  Disparity of in vitro and in vivo oleic acid-enhanced beta-estradiol percutaneous absorption across human skin.

Authors:  L K Pershing; G E Parry; L D Lambert
Journal:  Pharm Res       Date:  1993-12       Impact factor: 4.200

6.  Structure/effect studies of fatty acid isomers as skin penetration enhancers and skin irritants.

Authors:  B J Aungst
Journal:  Pharm Res       Date:  1989-03       Impact factor: 4.200

7.  Nasal membrane and intracellular protein and enzyme release by bile salts and bile salt-fatty acid mixed micelles: correlation with facilitated drug transport.

Authors:  Z Shao; A K Mitra
Journal:  Pharm Res       Date:  1992-09       Impact factor: 4.200

8.  Mechanism of ethanol-enhanced estradiol permeation across human skin in vivo.

Authors:  L K Pershing; L D Lambert; K Knutson
Journal:  Pharm Res       Date:  1990-02       Impact factor: 4.200

9.  Solute absorption from the airways of the isolated rat lung. II. Effect of surfactants on absorption of fluorescein.

Authors:  R W Niven; P R Byron
Journal:  Pharm Res       Date:  1990-01       Impact factor: 4.200

10.  Percutaneous penetration of acyclovir through excised hairless mouse and rat skin: effect of vehicle and percutaneous penetration enhancer.

Authors:  H Okamoto; K Muta; M Hashida; H Sezaki
Journal:  Pharm Res       Date:  1990-01       Impact factor: 4.200

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