Literature DB >> 4019637

Formation and metabolism of pungent principle of Capsicum fruits. XV. Microdetermination of capsaicin by high-performance liquid chromatography with electrochemical detection.

T Kawada, T Watanabe, K Katsura, H Takami, K Iwai.   

Abstract

A new, highly sensitive method for quantitative separation and determination of capsaicin and dihydrocapsaicin by high-performance liquid chromatography with electrochemical detection is elaborated. The method employs a Cosmosil 5Ph column eluted with 100 mM potassium dihydrogenphosphate containing 45% acetonitrile (pH 5.0) at a flow-rate of 1.0 ml/min, and an electrochemical detector (at a potential of +750 mV versus the Ag/AgCl electrode). The detection limits for both capsaicin and dihydrocapsaicin were 12 pg (39 fmol) at a signal-to-noise ratio of 3:1. By applying this method, the biological half-life of capsaicin in the rat was investigated.

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Year:  1985        PMID： 4019637     DOI： 10.1016/s0021-9673(01)81899-9

Source DB:  PubMed          Journal:  J Chromatogr


  6 in total

1.  Where did the chili get its spice? Biogeography of capsaicinoid production in ancestral wild chili species.

Authors:  Joshua J Tewksbury; Carlos Manchego; David C Haak; Douglas J Levey
Journal:  J Chem Ecol       Date:  2006-03-30       Impact factor: 2.626

2.  Design and in vitro evaluation of capsaicin transdermal controlled release cubic phase gels.

Authors:  Xinsheng Peng; Xinguo Wen; Xin Pan; Rongchang Wang; Bao Chen; Chuanbin Wu
Journal:  AAPS PharmSciTech       Date:  2010-09-14       Impact factor: 3.246

3.  Capsaicin induces apoptosis in human small cell lung cancer via the TRPV6 receptor and the calpain pathway.

Authors:  Jamie K Lau; Kathleen C Brown; Aaron M Dom; Theodore R Witte; Brent A Thornhill; Clayton M Crabtree; Haley E Perry; J Michael Brown; John G Ball; Rebecca G Creel; C Luke Damron; William D Rollyson; Cathryn D Stevenson; W Elaine Hardman; Monica A Valentovic; A Betts Carpenter; Piyali Dasgupta
Journal:  Apoptosis       Date:  2014-08       Impact factor: 4.677

Review 4.  Bioavailability of capsaicin and its implications for drug delivery.

Authors:  William D Rollyson; Cody A Stover; Kathleen C Brown; Haley E Perry; Cathryn D Stevenson; Christopher A McNees; John G Ball; Monica A Valentovic; Piyali Dasgupta
Journal:  J Control Release       Date:  2014-10-12       Impact factor: 9.776

5.  Development of a HPLC Method for the Quantitative Determination of Capsaicin in Collagen Sponge.

Authors:  Chun-Lian Guo; Hong-Ying Chen; Bi-Ling Cui; Yu-Huan Chen; Yan-Fang Zhou; Xin-Sheng Peng; Qin Wang
Journal:  Int J Anal Chem       Date:  2015-11-03       Impact factor: 1.885

6.  Bioavailability of a Capsaicin Lipid Multi-particulate Formulation in Rats.

Authors:  Kazim Sahin; Osman Kucuk; Cemal Orhan; Emre Sahin; Kelli Fowler; Tyler White; Shane Durkee; Aouatef Bellamine
Journal:  Eur J Drug Metab Pharmacokinet       Date:  2021-07-21       Impact factor: 2.441
  6 in total

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