| Literature DB >> 4018929 |
E Puigdellívol, M E Carral, J Moreno, J M Plà-Delfina, F Jané.
Abstract
The bioavailability of tranexamic acid after the administration of a single intramuscular dose was estimated in three healthy male volunteers. 500 mg tranexamic acid were given intramuscularly and intravenously, as a bolus injection, to each subject on separate occasions. Following intramuscular administration, the peak plasma concentrations were attained after approximately one hour and the apparent elimination half-life was about two hours. The absolute bioavailability was 105.2 +/- 10.7% (mean +/- SD). At the dose given, the bioavailability of tranexamic acid after intramuscular administration is fast and complete.Entities:
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Year: 1985 PMID： 4018929
Source DB: PubMed Journal: Int J Clin Pharmacol Ther Toxicol ISSN： 0174-4879